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. 2022 Aug;12(4):171-184.
doi: 10.2217/nmt-2021-0043. Epub 2022 May 23.

The 5-Cog paradigm to improve detection of cognitive impairment and dementia: clinical trial protocol

Rachel Chalmer  1 , Emmeline Ayers  2 , Erica F Weiss  2 , Rubina Malik  1 , Amy Ehrlich  1 , Cuiling Wang  3 , Jessica Zwerling  2 , Asif Ansari  1 , Katherine L Possin  4 , Joe Verghese  1   2
Affiliations

The 5-Cog paradigm to improve detection of cognitive impairment and dementia: clinical trial protocol

Rachel Chalmer et al. Neurodegener Dis Manag. 2022 Aug.

Abstract

Cognitive impairment related to dementia is under-diagnosed in primary care despite availability of numerous cognitive assessment tools; under-diagnosis is more prevalent for members of racial and ethnic minority groups. Clinical decision-support systems may improve rates of primary care providers responding to positive cognitive assessments with appropriate follow-up. The 5-Cog study is a randomized controlled trial in 1200 predominantly Black and Hispanic older adults from an urban underserved community who are presenting to primary care with cognitive concerns. The study will validate a novel 5-minute cognitive assessment coupled with an electronic medical record-embedded decision tree to overcome the barriers of current cognitive assessment paradigms in primary care and facilitate improved dementia care.

Trial registration: ClinicalTrials.gov NCT03816644.

Keywords: clinical trial protocol; cognitive assessment; cognitive impairment; cognitive screening; dementia; dissemination and implementation science; randomized controlled trial.

Plain language summary

Dementia is common, though under-recognized, in older adults (OAs). Primary care providers (PCPs) miss opportunities to help patients and their families manage the disease because of failure to, or delay to, make an appropriate diagnosis. Black and Hispanic OAs are more likely than White OAs to experience delayed diagnosis. Most available memory tests are too long for practical use by PCPs, and are ill suited to patients of diverse language, cultural and educational backgrounds. Studies have shown that even when patients test positive for dementia in primary care, PCPs often do not take follow-up action. Our improved memory test, the 5-Cog, is brief (5 min), not biased by language issues (uses pictures and symbols instead of words), and simple (doesn't require expensive technology and complex staff training). The 5-Cog is paired with a clinical decision support tool, providing tailored recommendations directly into the patient's medical record, and making it easier for PCPs to take appropriate action. This study will evaluate whether the 5-Cog paradigm results in improved dementia care.

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Figures

Figure 1.
Figure 1.. Study Flow.
*“Yes” on flyer and/or concern provided by staff member. †lf insufficient time, patient offered enrollment at next PCP visit. ‡Some participants return to RA for neuropsychological battery. §“Yes” on flyer and/or concern provided by staff/family member and negative on COVlD-19 screen. EMR: Electronic medical record; LPN: Licensed practical nurse; PCP: Primary care provider; PSR: Patient services representative; pt: Patient; RA: Research assistant.
Figure 2.
Figure 2.. Decision tree ‘branches’ with turnkey recommendations.
PMIS: Picture-Based Memory Impairment Screen.
See this image and copyright information in PMC

References

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