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. 2022 Aug;28(8):1240-1248.
doi: 10.1111/cns.13868. Epub 2022 May 23.

Prior statin and short-term outcomes of primary intracerebral hemorrhage: From a large-scale nationwide longitudinal registry

Guangshuo Li  1 , Shang Wang  2 , Yunyun Xiong  1   3   4 , Hongqiu Gu  4 , Kaixuan Yang  4 , Xin Yang  4   5 , Chunjuan Wang  4   5 , Chuanying Wang  1 , Zixiao Li  1   3   4   6   7 , Xingquan Zhao  1   4
Affiliations

Prior statin and short-term outcomes of primary intracerebral hemorrhage: From a large-scale nationwide longitudinal registry

Guangshuo Li et al. CNS Neurosci Ther. 2022 Aug.

Abstract

Introduction: The relationship between statins and intracerebral hemorrhage outcomes is unclear.

Aim: We aimed to compare the in-hospital mortality and evacuation of intracranial hematoma rates in patients with primary intracerebral hemorrhage between prior statin users and nonusers.

Results: The final study population included 66,263 patients. Multivariable logistics analyses showed that prior statin use was not associated with in-hospital mortality for primary intracerebral hemorrhage (adjusted odd ratio 0.78, 95% CI 0.61-1.01), but reduced the proportion of patients undergoing evacuation of intracranial hematoma (adjusted odd ratio 0.70, 95% CI 0.61-0.82). Propensity score matching analyses yielded similar results.

Conclusion: Prior statin use was not associated with in-hospital mortality but did reduce evacuation of intracranial hematoma rates.

Keywords: cerebral hemorrhage; hydroxymethylglutaryl-CoA reductase inhibitors; mortality; treatment outcome.

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Conflict of interest statement

None.

Figures

FIGURE 1
FIGURE 1
Logistics regression analyses of clinical outcomes. Adjusted: Adjusted for medical history of hypertension, diabetes mellitus, dyslipidemia, atrial fibrillation, myocardial infarction, heart failure, ischemic stroke, cerebral hemorrhage, mediation history of antiplatelet agents, anticoagulant agents, antihypertensive agents, antidiabetic agents, fasting plasma glucose, systolic blood pressure, diastolic blood pressure and INR. PSM, propensity score matching
FIGURE 2
FIGURE 2
Subgroup analysis of in‐hospital mortality. Adjusted: Adjusted for medical history of hypertension, diabetes mellitus, dyslipidemia, atrial fibrillation, myocardial infarction, heart failure, ischemic stroke, cerebral hemorrhage, mediation history of antiplatelet agents, anticoagulant agents, antihypertensive agents, antidiabetic agents, fasting plasma glucose, systolic blood pressure, diastolic blood pressure, and INR. PSM, propensity score matching
FIGURE 3
FIGURE 3
Subgroup analysis of evacuation of intracranial hematoma. Adjusted: Adjusted for medical history of hypertension, diabetes mellitus, dyslipidemia, atrial fibrillation, myocardial infarction, heart failure, ischemic stroke, cerebral hemorrhage, mediation history of antiplatelet agents, anticoagulant agents, antihypertensive agents, antidiabetic agents, fasting plasma glucose, systolic blood pressure, diastolic blood pressure and INR. PSM, propensity score matching
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References

    1. Cordonnier C, Demchuk A, Ziai W, Anderson CS. Intracerebral haemorrhage: current approaches to acute management. Lancet. 2018;392(10154):1257‐1268. - PubMed
    1. Krishnamurthi RV, Feigin VL, Forouzanfar MH, et al. Global and regional burden of first‐ever ischaemic and haemorrhagic stroke during 1990–2010: findings from the Global Burden of Disease Study 2010. Lancet Glob Health. 2013;1(5):e259‐e281. - PMC - PubMed
    1. van Asch CJJ, Luitse MJA, Rinkel GJE, van der Tweel I, Algra A, Klijn CJM. Incidence, case fatality, and functional outcome of intracerebral haemorrhage over time, according to age, sex, and ethnic origin: a systematic review and meta‐analysis. Lancet Neurol. 2010;9(2):167‐116. - PubMed
    1. Amarenco P, Bogousslavsky J, Callahan A 3rd, et al. High‐dose atorvastatin after stroke or transient ischemic attack. N Engl J Med. 2006;355(6):549‐559. - PubMed
    1. Asberg S, Eriksson M. Statin therapy and the risk of intracerebral haemorrhage: a nationwide observational study. Int J Stroke. 2015;10(Suppl A100):46‐49. - PubMed

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