doi: 10.1073/pnas.75.7.3099.
ATP-induced conformational changes in the restriction endonuclease from Escherichia coli K-12
- PMID: 356045
- PMCID: PMC392721
- DOI: 10.1073/pnas.75.7.3099
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ATP-induced conformational changes in the restriction endonuclease from Escherichia coli K-12
Proc Natl Acad Sci U S A.
1978 Jul.
Abstract
ATP induces a conformational change in the Escherichia coli K-12 restriction enzyme that allows it to discriminate between unmodified and modified DNA recognition sequences. This conformational change does not require ATP hydrolysis. However, ATP hydrolysis is a requirement for DNA cleavage.
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