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. 1978 Jul;75(7):3099-103.
doi: 10.1073/pnas.75.7.3099.

ATP-induced conformational changes in the restriction endonuclease from Escherichia coli K-12

T A Bickle, C Brack, R Yuan

ATP-induced conformational changes in the restriction endonuclease from Escherichia coli K-12

T A Bickle et al. Proc Natl Acad Sci U S A. 1978 Jul.

Abstract

ATP induces a conformational change in the Escherichia coli K-12 restriction enzyme that allows it to discriminate between unmodified and modified DNA recognition sequences. This conformational change does not require ATP hydrolysis. However, ATP hydrolysis is a requirement for DNA cleavage.

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References

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