Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Oct;49(10):10065-10076.
doi: 10.1007/s11033-022-07590-z. Epub 2022 May 23.

The deadly cross-talk between Hippo pathway and epithelial-mesenchymal transition (EMT) in cancer

Ioanna Akrida  1   2 , Vasiliki Bravou  3 , Helen Papadaki  3
Affiliations
Review

The deadly cross-talk between Hippo pathway and epithelial-mesenchymal transition (EMT) in cancer

Ioanna Akrida et al. Mol Biol Rep. 2022 Oct.

Abstract

Hippo signaling pathway is an evolutionarily conserved network that regulates organ size growth and tissue regeneration. Hippo signaling dysfunction results in uncontrolled cell proliferation and influences cell differentiation. Aberrant Hippo pathway signaling is implicated in cancer progression, by promoting cell proliferation, cancer stem cell properties, chemoresistance and metastatic capacity. Epithelial-mesenchymal transition (EMT) is also well known to be implicated in carcinogenesis. Loss of cell polarity, disruption of cell-cell junctions and cytoskeletal remodeling are essential during EMT. At the same time, signals related to intercellular contact, cell-extracellular matrix contact, polarity and mechanotransduction are included in the list of regulatory inputs into Hippo pathway. Therefore, the emerging association between Hippo pathway and EMT in cancer is not surprising. Recent studies have begun to unravel the mechanisms of interaction between Hippo signaling pathway and EMT. In this review, we describe the existing evidence of cross talk between Hippo signaling pathway key molecules and the process of EMT, with emphasis on the role of Hippo-EMT interplay in cancer.

Keywords: Cancer; Epithelial–mesenchymal transition (EMT); Hippo pathway; Snail; YAP/TAZ; ZEB.

PubMed Disclaimer

References

    1. Zygulska AL, Krzemieniecki K, Pierzchalski P (2017) Hippo pathway—brief overview of its relevance in cancer. J Physiol Pharmacol 68(3):311–335 - PubMed
    1. Wang Y, Xu X, Maglic D, Dill MT, Mojumdar K, Ng PK, Jeong KJ, Tsang YH, Moreno D, Bhavana VH, Peng X, Ge Z, Chen H, Li J, Chen Z, Zhang H, Han L, Du D, Creighton CJ, Mills GB (2018) Comprehensive molecular characterization of the Hippo signaling pathway in cancer. Cell Rep 25(5):1304-1317.e5. https://doi.org/10.1016/j.celrep.2018.10.001 - DOI - PubMed - PMC
    1. Lian I, Kim J, Okazawa H, Zhao J, Zhao B, Yu J, Chinnaiyan A, Israel MA, Goldstein LS, Abujarour R, Ding S, Guan KL (2010) The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation. Genes Dev 24(11):1106–1118. https://doi.org/10.1101/gad.1903310 - DOI - PubMed - PMC
    1. Morice S, Danieau G, Rédini F, Brounais-Le-Royer B, Verrecchia F (2020) Hippo/YAP signaling pathway: a promising therapeutic target in bone paediatric cancers? Cancers (Basel) 12(3):645. https://doi.org/10.3390/cancers12030645 - DOI
    1. Kalluri R, Weinberg RA (2009) The basics of epithelial–mesenchymal transition. J Clin Investig 119(6):1420–1428. https://doi.org/10.1172/JCI39104 - DOI - PubMed - PMC

MeSH terms

Substances

LinkOut - more resources