Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2022 May 23;17(5):e0268903.
doi: 10.1371/journal.pone.0268903. eCollection 2022.

Neospora caninum infection in aborting bovines and lost fetuses: A systematic review and meta-analysis

Tooran Nayeri  1   2   3 , Mahmood Moosazadeh  4 , Shahabeddin Sarvi  1   2 , Ahmad Daryani  1   2
Affiliations
Meta-Analysis

Neospora caninum infection in aborting bovines and lost fetuses: A systematic review and meta-analysis

Tooran Nayeri et al. PLoS One. .

Abstract

Background: Neospora caninum (N. caninum) is known to be a major cause of reproductive failure in cattle herds around the world. Therefore, the current comprehensive study was performed to estimate the global prevalence of N. caninum infection in bovines that had an abortion and aborted fetuses.

Methods: In this study, PubMed, ScienceDirect, Web of Science, Scopus, and ProQuest databases were systematically searched for relevant studies up until November 4, 2021. Pooled prevalence and corresponding 95% confidence intervals (CI) were estimated using a random effect model. Other analyzes performed on the data of this study include sensitivity analysis, publication bias test, and quality assessment.

Results: The final analyses included 71 studies conducted on 2965 abortive cattle and 4805 aborted fetuses. The overall prevalence rates of N. caninum infection in bovines that had an abortion were 47% and 1% using serological and molecular methods. Furthermore, overall prevalence rates of N. caninum infection in bovine aborted fetuses globally were 35% (95% CI: 8%-62%) and 43% (95% CI: 35%-52%) using serological and molecular methods.

Conclusions: The results of this study showed the high prevalence of N. caninum infection in bovines that had an abortion and aborted fetuses. It is hoped that the results of this study will help prevent abortion in bovines around the world and encourage further studies to determine the impact of this parasite on the occurrence of abortion that may help reduce the economic damage caused by abortion worldwide.

PubMed Disclaimer

Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Flow diagram of the study design process.
Fig 2
Fig 2. The reported seroprevalence rate of anti- N. caninum antibodies in bovines that had an abortion by serological methods.
Fig 3
Fig 3. The pooled seroprevalence rate of anti- N. caninum antibodies in the bovine aborted fetuses.
Fig 4
Fig 4. The prevalence of N. caninum infection in the bovine aborted fetuses using molecular methods.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Shaapan RM. The common zoonotic protozoal diseases causing abortion. J Parasit Dis. 2016;40(4):1116–29. doi: 10.1007/s12639-015-0661-5 - DOI - PMC - PubMed
    1. Dubey J, Schares G. Diagnosis of bovine neosporosis. Vet Parasitol. 2006;140(1–2):1–34. doi: 10.1016/j.vetpar.2006.03.035 - DOI - PubMed
    1. Dubey JP. Review of Neospora caninum and neosporosis in animals. Korean J Parasitol. 2003;41(1):1. doi: 10.3347/kjp.2003.41.1.1 - DOI - PMC - PubMed
    1. McAllister MM, Björkman C, Anderson-Sprecher R, Rogers DG. Evidence of point-source exposure to Neospora caninum and protective immunity in a herd of beef cows. J Am Vet Med Assoc. 2000;217(6):881–7. doi: 10.2460/javma.2000.217.881 - DOI - PubMed
    1. Trees AJ, Williams DJ. Endogenous and exogenous transplacental infection in Neospora caninum and Toxoplasma gondii. Trends Parasitol. 2005;21(12):558–61. doi: 10.1016/j.pt.2005.09.005 - DOI - PubMed

Substances