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Comment
. 2022 Aug;85(2):174-211.
doi: 10.1016/j.jinf.2022.05.016. Epub 2022 May 20.

Immune responses to COVID-19 vaccine BNT162b2 in workers at a research institute in Japan: 6-month follow-up survey

Akihiko Nishikimi  1 , Ken Watanabe  2 , Atsushi Watanabe  3 , Mikako Yasuoka  4 , Ryota Watanabe  4 , Mitsuhiro Fujiwara  5 , Hironori Oshima  6 , Takeshi Nakagawa  7 , Yuichi Kitagawa  8 , Haruhiko Tokuda  9 , Yukihiko Washimi  10 , Shumpei Niida  11 , Masayo Kojima  4
Affiliations
Comment

Immune responses to COVID-19 vaccine BNT162b2 in workers at a research institute in Japan: 6-month follow-up survey

Akihiko Nishikimi et al. J Infect. 2022 Aug.
No abstract available

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Conflict of interest statement

Declarations of Competing Interest None.

Figures

Fig 1
Fig. 1
Antibody titer and T-cell response following the second dose of the BNT162b2 vaccine. (A) Correlation between age and S-IgG levels 1–4 months after the second vaccination dose was measured using Sysmex test. Spearman r, as well as p-values, are presented in each graph. (B) Comparison of antibody levels among different age groups and between the sexes. Data are expressed as box plots: middle line, median; box edges, 25th–75th centile. ***p < 0.001. (C) Kinetics of the antibody titers following the second dose of the vaccine. Correlation between S-IgG levels and the number of days after the second dose. (D) Cellular immunity of participants who failed to develop antibodies against SARS-CoV-2 after the second dose of the vaccine. The number of spot-forming cells per 250,000 in the panel 1 of T-SPOT test was plotted based on the antibody-level groups. The horizontal solid lines indicate the mean of spot-forming cell numbers. The dashed line indicates the threshold of T-SPOT values.
Fig 2
Fig. 2
Anti-spike IgG levels at 5–6 months following the second dose of the BNT162b2 vaccine. (A) Kinetics of anti-spike IgG levels of each participant as measured by the Sysmex test. The median values of each data point are displayed as solid black circles connected with solid black lines. Shaded areas in blue indicate the 25%–75% percentile. (B) Correlation between age and S-IgG levels in the December survey as measured with the Sysmex test. (C) Comparison of antibody levels among the different age groups and between the sexes. Data are expressed as box plots: middle line, median; box edges, 25th–75th centile.
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Comment on

References

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