[Antithrombogenic properties of the vascular walls and intravascular platelet activation in ischemic heart disease]

Abstract

A study of 150 coronary patients demonstrated compromized athrombogenic endothelial properties, as compared to normal subjects whose vascular wall endothelial cells show high anti-aggregation and anti-coagulant activity and prevent intravascular platelet aggregation. The cuff test performed in coronary patients during acute myocardial infarction or an anginal attack induced no release of prostacycline, antithrombin III or plasminogen activators from endothelial cells into the blood flow. Coronary patients demonstrated intravascular platelet activation, impaired platelet release and increased factor 4, thromboxane B2 and beta-thromboglobulin levels.