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. 2022 Apr 20;14(4):e24305.
doi: 10.7759/cureus.24305. eCollection 2022 Apr.

Outcomes of Primary Mucosal Head and Neck Squamous Cell Carcinoma in Solid Organ Transplant Recipients

Marissa Gilbert  1 , Evan Liang  1 , Pin Li  2 , Reena Salgia  3 , Marwan Abouljoud  4 , Farzan Siddiqui  1
Affiliations

Outcomes of Primary Mucosal Head and Neck Squamous Cell Carcinoma in Solid Organ Transplant Recipients

Marissa Gilbert et al. Cureus. .

Abstract

Introduction Patients who undergo solid organ transplants have a higher risk of developing malignancies and subsequent recurrences. Clinical outcomes in transplant recipients with primary mucosal head and neck squamous cell carcinoma (HNSCC) are not well described in the published literature. Therefore, we retrospectively studied the outcomes in this group of patients. Methods This Institutional Review Board (IRB)-approved analysis included patients who had previously undergone solid organ transplants and subsequently were diagnosed with primary mucosal HNSCC between 2006 and 2021. Our institutional database of solid organ transplant recipients was cross-referenced with our head and neck cancer database to identify the patients included in this cohort. In addition, Kaplan-Meier analyses were performed to calculate overall and disease-free survival. Results Of 1,221 patients, 20 met the inclusion criteria. The median time from organ transplant to HNSCC diagnosis was 5.9 years (range: 0.5-18.5 years). A total of 11 (55.0%) and 9 (45.0%) patients presented with localized and locally advanced disease, respectively. Two-year overall and disease-free survivals were 59.1% and 73.5%, respectively. After initial treatment, six (30.0%) patients experienced a recurrence. All patients who developed a recurrence died within the follow-up period. The median time of death after recurrence for all six patients was 11.5 months (range: 2-22 months). Conclusion This series highlights a high mortality rate following recurrence among patients with primary mucosal HNSCC and a solid organ transplant history. A better understanding of how solid organ transplant history adversely impacts the course of HNSCC could help properly guide treatment, follow-up, and survivorship decisions.

Keywords: head and neck; locoregional recurrence; organ transplant; radiation therapy; squamous cell carcinoma.

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Conflict of interest statement

The authors have declared financial relationships, which are detailed in the next section.

Figures

Figure 1
Figure 1. Overall survival for solid organ transplant patients subsequently diagnosed with HNSCC.
HNSCC: Head and neck squamous cell carcinoma.
Figure 2
Figure 2. Locoregional control for solid organ transplant patients diagnosed with HNSCC that later presented with recurrence.
HNSCC: Head and neck squamous cell carcinoma.
See this image and copyright information in PMC

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References

    1. Spectrum of cancer risk among US solid organ transplant recipients. Engels EA, Pfeiffer RM, Fraumeni JF Jr, et al. JAMA. 2011;306:1891–1901. - PMC - PubMed
    1. A population-based study of skin cancer incidence and prevalence in renal transplant recipients. Moloney FJ, Comber H, O'Lorcain P, O'Kelly P, Conlon PJ, Murphy GM. Br J Dermatol. 2006;154:498–504. - PubMed
    1. Skin cancer in solid organ transplant recipients: advances in therapy and management: part II. Management of skin cancer in solid organ transplant recipients. O'Reilly Zwald F, Brown M. J Am Acad Dermatol. 2011;65:263–279. - PubMed
    1. Skin cancer in organ transplant recipients. Kempf W, Mertz KD, Hofbauer GF, Tinguely M. Pathobiology. 2013;80:302–309. - PubMed
    1. Skin cancers after organ transplantation. Euvrard S, Kanitakis J, Claudy A. N Engl J Med. 2003;348:1681–1691. - PubMed

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