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. 2022 Nov 30;75(11):2023-2026.
doi: 10.1093/cid/ciac395.

Maternal and Neonatal Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Variant Neutralization After Antenatal Messenger RNA Vaccination

Amihai Rottenstreich  1 , Olesya Vorontsov  2 , Or Alfi  2 , Gila Zarbiv  1 , Esther Oiknine-Djian  2 , Roy Zigron  1 , Geffen Kleinstern  3 , Michal Mandelboim  4 , Shay Porat  1 , Dana G Wolf  2
Affiliations

Maternal and Neonatal Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Variant Neutralization After Antenatal Messenger RNA Vaccination

Amihai Rottenstreich et al. Clin Infect Dis. .

Abstract

We evaluated the neutralization efficiency against SARS-CoV-2 Omicron variant in maternal and cord blood sera after antenatal BNT162b2 vaccination. Neutralizing antibodies against Omicron were lacking at the time of delivery after 2-dose vaccination. A third booster dose was essential in building neutralizing antibody capacity against Omicron among mothers and neonates.

Keywords: COVID-19; Omicron; SARS-CoV-2; pregnancy; vaccination.

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Conflict of interest statement

Potential conflicts of interest. All authors: No reported conflicts of interest. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed.

Figures

Figure 1.
Figure 1.
Neutralizing antibody titers in maternal (A) and neonatal (B) sera against WT severe acute respiratory syndrome coronavirus 2 and the Delta and Omicron variants in those who completed the 2-dose vaccine series in the first, second, and third trimesters of pregnancy and those who additionally received a third booster dose. Neutralizing efficiency is reflected by NT50 values, measured in live virus microneutralization assay (see Methods section). The I bars represent 95% confidence intervals, and the circles represent the values in individual participants. The dashed line indicates the lower limit of detection of the assay (10). Samples with values below the lower limit of detection were assigned a value of 5. Abbreviations: NA, not available; NT50, neutralization titer; WT, wild type.
See this image and copyright information in PMC

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Supplementary concepts