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Review
. 2022 May;38(5):445-452.
doi: 10.1051/medsci/2022062. Epub 2022 May 24.

[Fatty acid synthase, a "multi-FASet" enzyme]

[Article in French]
Sadia Raab  1 , Tony Lefebvre  1
Affiliations
Free article
Review

[Fatty acid synthase, a "multi-FASet" enzyme]

[Article in French]
Sadia Raab et al. Med Sci (Paris). 2022 May.
Free article

Abstract
in English, French

In mammals, fatty acids are supplied by diet or synthesized de novo by fatty acid synthase (FASN). Beyond its key role in energy storage, FASN is involved in many biological processes. It actively participates in the synthesis of membrane components necessary for cell division, protein modification, cell signaling and cell proliferation. In this review, we discuss the various physiological functions of FASN as well as its involvement in cancer, the expression of the lipogenic enzyme being particularly high in this disease.

Title: L’acide gras synthase, une enzyme « multi-FASette ».

Abstract: Chez les mammifères, les acides gras sont fournis par l’alimentation ou sont synthétisés de novo par l’acide gras synthase (FASN pour fatty acid synthase). Au-delà de son rôle clé dans le stockage de l’énergie, FASN est impliquée dans de nombreux processus biologiques. Elle participe activement à la synthèse des composants membranaires nécessaires à la division cellulaire, à la modification des protéines, à la signalisation et à la prolifération cellulaires. Dans cette revue, nous discutons des diverses fonctions physiologiques de FASN ainsi que de son implication dans les cancers, l’expression de cette enzyme lipogénique étant particulièrement élevée dans cette maladie.

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References

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