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. 2022 Sep;46(9):e14253.
doi: 10.1111/jfbc.14253. Epub 2022 May 24.

Ginkgo biloba protects striatal neurodegeneration and gut phagoinflammatory damage in rotenone-induced mice model of Parkinson's disease: Role of executioner caspase-3/Nrf2/ARE signaling

Olusegun G Adebayo  1 , Jerome N Asiwe  2 , Benneth Ben-Azu  3 , Wadioni Aduema  4 , Ijeoma Onyeleonu  5 , Ajirioghene E Akpotu  6 , Iheanyichukwu Wopara  7 , Tolunigba A Kolawole  8 , Elizabeth B Umoren  1   9 , Vincent Igbokwe  1   10 , Buduchim R Buduburisi  1 , Favour C Onwuka  1 , Providence I Brown  8
Affiliations

Ginkgo biloba protects striatal neurodegeneration and gut phagoinflammatory damage in rotenone-induced mice model of Parkinson's disease: Role of executioner caspase-3/Nrf2/ARE signaling

Olusegun G Adebayo et al. J Food Biochem. 2022 Sep.

Abstract

Asymptomatic and early clinical stages of Parkinson's disease (PD) have been linked with comorbid non-motor symptoms including dysfunction of the gastrointestinal (GI) tract. Notwithstanding, neuroprotective and gastroprotective effects of Ginkgo biloba supplements (GBS) have been investigated independently. Hence, whether GBS-mediated GIT-protective capacity could be helpful in PD via gut-brain anti-inflammatory signaling still remains unknown. Treatment with GBS significantly repressed the motor behavioral and neuromuscular deficits and prevented loss of striatal dopaminergic loss by improving the level of tyrosine hydroxylase enzyme and suppressing synucleinopathy development. Striatal neurons and ileal epithelial injury following intraperitoneal rotenone administration were accompanied with oxidoinflammatory/nitroinflammatory stress and marked inhibition of cholinergic transmission. Moreover, there was increased striatal executioner caspase-3 and decreased nuclear factor erythroid-2-related factor 2 (Nrf2) immunoexpression, loss of striatal pyramidal neuron with a marked decrease in length and width of the dendritic spines as well as significant hyperplasia of cryptal cells in the ileal epithelial tissues, all which were reversed by the pretreatment + concurrent (Pre-CONC) and concurrent (CONC) GBS treatment pattern. In sum, we proved the potential dual effects of GBS in preventing both dopaminergic neural-related impairments and gut wall abnormalities linked with PD.

Keywords: Ginkgo biloba; Caspase-3; Parkinson's disease; myeloperoxidase; neurodegeneration; nuclear factor erythroid-2-related factor 2.

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References

REFERENCES

    1. Abdel-Salam, O. M., Baiuomy, A. R., El-Batran, S., & Arbid, M. S. (2004). Evaluation of the anti-inflammatory, anti-nociceptive and gastric effects of Ginkgo biloba in the rat. Pharmacological Research, 49(2), 133-142.
    1. Adebayo, O. G., Ben-Azu, B., Ajayi, A. M., Wopara, I., Aduema, W., Kolawole, T. A., Umoren, E. B., Onyeleonu, I., Ebo, O. T., Ajibo, D. N., & Akpotu, A. E. (2021). Gingko biloba abrogate lead-induced neurodegeneration in mice hippocampus: Involvement of NF-κB expression, myeloperoxidase activity and pro-inflammatory mediators. Biological Trace Element Research, 9, 1-4.
    1. Alabi, A. O., Ajayi, A. M., Ben-Azu, B., Bakre, A. G., & Umukoro, S. (2019). Methyl jasmonate abrogates rotenone-induced parkinsonian-like symptoms through inhibition of oxidative stress, release of pro-inflammatory cytokines, and down-regulation of immnopositive cells of NF-κB and α-synuclein expressions in mice. Neurotoxicology, 74, 172-183.
    1. Angulo, A., Fernandez, E., Merchan, J. A., & Molina, M. (1996). A reliable method for Golgi staining of retina and brain slices. Journal of Neuroscience Methods, 66, 55-59.
    1. Bell, J., Spencer, J., Yates, R., Yee, S., Jacobs, B., & Deluca, G. (2019). Invited Review: From nose to gut-the role of the microbiome in neurological disease. Neuropathology and Applied Neurobiology, 45, 195-215.

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