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Comment
. 2022 May 24;15(735):eadd1034.
doi: 10.1126/scisignal.add1034. Epub 2022 May 24.

A twist in β-arrestin's tail

John F Foley  1
Affiliations
Comment

A twist in β-arrestin's tail

John F Foley. Sci Signal. .

Abstract

Both agonist binding and phosphorylation of the receptor C-tail are required for a GPCR to recruit and activate β-arrestins.

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  • GPCR-mediated β-arrestin activation deconvoluted with single-molecule precision.
    Asher WB, Terry DS, Gregorio GGA, Kahsai AW, Borgia A, Xie B, Modak A, Zhu Y, Jang W, Govindaraju A, Huang LY, Inoue A, Lambert NA, Gurevich VV, Shi L, Lefkowitz RJ, Blanchard SC, Javitch JA. Asher WB, et al. Cell. 2022 May 12;185(10):1661-1675.e16. doi: 10.1016/j.cell.2022.03.042. Epub 2022 Apr 27. Cell. 2022. PMID: 35483373 Free PMC article.

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