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Review
. 2022 Jun;42(3):479-486.
doi: 10.19852/j.cnki.jtcm.20220408.003.

Integration strategy of network pharmacology in Traditional Chinese Medicine: a narrative review

W U Jiashuo  1 , Zhang Fangqing  1 , L I Zhuangzhuang  1 , Jin Weiyi  2 , Shi Yue  1
Affiliations
Review

Integration strategy of network pharmacology in Traditional Chinese Medicine: a narrative review

W U Jiashuo et al. J Tradit Chin Med. 2022 Jun.

Abstract

Traditional Chinese Medicine (TCM) has been extensively used as a mainstay for treating various pathologies. Combing the pharmacology and systems biology approaches, the network pharmacology (NP) approach was developed to predict the probable mechanism underlying the therapeutic effect of TCM. However, approaches solely based on NP cannot effectively elucidate the curative mechanism in a holistic and reliable manner due to limitations in NP-based methods and complexity of TCM components. Thus, integration strategies combining NP with other approaches are increasingly being used. Since the interdisciplinary research in TCM has received much attention in the advent of the big data era of which the NP-based integration strategy is broadly used, the strategy is clearly elaborated in the present review. We summarized several NP-based integration strategies and their applications in TCM studies, including multi-omics approach, gut microbiota study, chemical information analysis, data-mining, and network toxicology study.

Keywords: Chinese traditional; integration strategy; medicine; network pharmacology; review; toxicology.

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Figure 1
Figure 1. Integration strategy of network pharmacologyThe Venn diagram reflects the interdisciplinary approach based on network pharmacology.
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