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. 2022 Jul 5;50(W1):W272-W275.
doi: 10.1093/nar/gkac348.

DrugVirus.info 2.0: an integrative data portal for broad-spectrum antivirals (BSA) and BSA-containing drug combinations (BCCs)

Aleksandr Ianevski  1 , Ronja M Simonsen  1 , Vegard Myhre  1 , Tanel Tenson  2 , Valentyn Oksenych  3 , Magnar Bjørås  1   4 , Denis E Kainov  1   2   5
Affiliations

DrugVirus.info 2.0: an integrative data portal for broad-spectrum antivirals (BSA) and BSA-containing drug combinations (BCCs)

Aleksandr Ianevski et al. Nucleic Acids Res. .

Abstract

Viruses can cross species barriers and cause unpredictable outbreaks in man with substantial economic and public health burdens. Broad-spectrum antivirals, (BSAs, compounds inhibiting several human viruses), and BSA-containing drug combinations (BCCs) are deemed as immediate therapeutic options that fill the void between virus identification and vaccine development. Here, we present DrugVirus.info 2.0 (https://drugvirus.info), an integrative interactive portal for exploration and analysis of BSAs and BCCs, that greatly expands the database and functionality of DrugVirus.info 1.0 webserver. Through the data portal that now expands the spectrum of BSAs and provides information on BCCs, we developed two modules for (i) interactive analysis of users' own antiviral drug and combination screening data and their comparison with published datasets, and (ii) exploration of the structure-activity relationship between various BSAs. The updated portal provides an essential toolbox for antiviral drug development and repurposing applications aiming to identify existing and novel treatments of emerging and re-emerging viral threats.

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Figures

Graphical Abstract
Graphical Abstract
DrugVirus.info 2.0 is an integrative portal for exploration and analysis of broad-spectrum antiviral drugs and drug combinations, aiming to help in identifing existing and novel treatments of emerging and re-emerging viral threats.
Figure 1.
Figure 1.
Overview of DrugVirus.info 2.0 portal. (A) The portal comprises three major components BSA and BCC databases, module for analysis and comparison of user-provided BSAs and BCCs data, and structure–activity relation (SAR) module. (B) The circular dendrogram shows the SAR of 250 BSAs and stages of their development against SARS-CoV-2. (C, D) Example of analysis of user-provided data for single BSA and comparison of resulting selectivity indexes (SI = CC50/EC50) obtained for other viruses. (E) Example of automated calculation and visualization of BCC synergy score analysis.
See this image and copyright information in PMC

References

    1. Zhu J.D., Meng W., Wang X.J., Wang H.C.R.. Broad-spectrum antiviral agents. Front. Microbiol. 2015; 6:517. - PMC - PubMed
    1. Ianevski A., Zusinaite E., Kuivanen S., Strand M., Lysvand H., Teppor M., Kakkola L., Paavilainen H., Laajala M., Kallio-Kokko H.et al.. Novel activities of safe-in-human broad-spectrum antiviral agents. Antivir. Res. 2018; 154:174–182. - PMC - PubMed
    1. Andersen P.I., Ianevski A., Lysvand H., Vitkauskiene A., Oksenych V., Bjørås M., Telling K., Lutsar I., Dumpis U., Irie Y.et al.. Discovery and development of safe-in-man broad-spectrum antiviral agents. Int. J. Infect. Dis. 2020; 93:268–276. - PMC - PubMed
    1. Adalja A., Inglesby T.. Broad-spectrum antiviral agents: a crucial pandemic tool. Expert Rev. Anti-Infect. Ther. 2019; 17:467–470. - PMC - PubMed
    1. Ianevski A., Yao R., Simonsen R.M., Myhre V., Ravlo E., Kaynova G.D., Zusinaite E., White J.M., Polyak S.J., Oksenych V.et al.. Mono- and combinational drug therapies for global viral pandemic preparedness. Iscience. 2022; 17:104112. - PMC - PubMed

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