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Comment
. 2022 Jul;28(7):531-532.
doi: 10.1016/j.molmed.2022.05.002. Epub 2022 May 22.

A new day for human challenge trials?

Abie Rohrig  1 , Nir Eyal  2
Affiliations
Comment

A new day for human challenge trials?

Abie Rohrig et al. Trends Mol Med. 2022 Jul.

Abstract

Two years into the coronavirus disease 2019 (COVID-19) pandemic and following several hot debates, the world's first COVID-19 human challenge trial has recently been published by Killingley et al. We review its findings and explain why this particular juncture in time makes additional challenge trials for COVID-19 and for other diseases justified and important.

Keywords: COVID-19; controlled human infection model; human challenge trials; research ethics; vaccine ethics.

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Conflict of interest statement

Declaration of interests N.E. serves on the Board of Advisors of 1Day Sooner, an unpaid position. He declares having no financial conflicts of interest. A.R. reports affiliation with 1Day Sooner throughout the writing of the article.

Comment on

  • Safety, tolerability and viral kinetics during SARS-CoV-2 human challenge in young adults.
    Killingley B, Mann AJ, Kalinova M, Boyers A, Goonawardane N, Zhou J, Lindsell K, Hare SS, Brown J, Frise R, Smith E, Hopkins C, Noulin N, Löndt B, Wilkinson T, Harden S, McShane H, Baillet M, Gilbert A, Jacobs M, Charman C, Mande P, Nguyen-Van-Tam JS, Semple MG, Read RC, Ferguson NM, Openshaw PJ, Rapeport G, Barclay WS, Catchpole AP, Chiu C. Killingley B, et al. Nat Med. 2022 May;28(5):1031-1041. doi: 10.1038/s41591-022-01780-9. Epub 2022 Mar 31. Nat Med. 2022. PMID: 35361992 Clinical Trial.

References

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