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Case Reports
. 2022 Apr 16;10(11):3624-3629.
doi: 10.12998/wjcc.v10.i11.3624.

Thyrotoxicosis after a massive levothyroxine ingestion: A case report

Fang Du  1 , Shi-Wei Liu  2 , Hua Yang  3 , Rui-Xue Duan  3 , Wen-Xia Ren  3
Affiliations
Case Reports

Thyrotoxicosis after a massive levothyroxine ingestion: A case report

Fang Du et al. World J Clin Cases. .

Abstract

Background: The literature on thyrotoxicosis caused by excessive ingestion of exogenous thyroid hormone is limited, and most cases reported have involved pediatric clinical studies.

Case summary: A 21-year-old woman initially presented with palpitation and chest tightness after an overdose of levothyroxine (10 mg). The patient transiently lost consciousness and developed atrial fibrillation during hospitalization. We used propylthiouracil to decrease the peripheral conversion of T4 to T3 and inhibit the synthesis of endogenous thyroxine, propranolol to control heart rate, hydrocortisone to correct severe thyrotoxicosis, and hemoperfusion to increase levothyroxine clearance. The patient recovered and was discharged.

Conclusion: For patients with thyrotoxicosis after taking excess levothyroxine, it is critical to monitor vital signs and initiate effective treatment.

Keywords: Case report; Levothyroxine; Overdose; Thyroid crisis; Thyrotoxicosis; Treatment.

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Conflict of interest statement

Conflict-of-interest statement: The authors declare that they have no conflicting interests.

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