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Comment
. 2022 Jun 1;50(6):e599-e600.
doi: 10.1097/CCM.0000000000005505. Epub 2022 May 19.

Is Early Vasopressor Safe in Septic Shock?

Siddharth Dugar  1   2 , Ashish K Khanna  3   4 , Abhijit Duggal  1   2
Affiliations
Comment

Is Early Vasopressor Safe in Septic Shock?

Siddharth Dugar et al. Crit Care Med. .
No abstract available

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Conflict of interest statement

Dr. Khanna received funding from Edwards Lifesciences, Philips North America, La Jolla Pharmaceuticals, and grant support for the Angiotensin II for the Treatment of High-Output Shock phase 3 (ATHOS3) trial. The remaining authors have disclosed that they do not have any potential conflicts of interest.

Comment in

  • The authors reply.
    Yeo HJ, Cho WH. Yeo HJ, et al. Crit Care Med. 2022 Jun 1;50(6):e600-e601. doi: 10.1097/CCM.0000000000005521. Epub 2022 May 19. Crit Care Med. 2022. PMID: 35612452 No abstract available.

Comment on

References

    1. Yeo HJ, Lee YS, Kim TH, et al.; Korean Sepsis Alliance (KSA) Investigators: Vasopressor initiation within 1 hour of fluid loading is associated with increased mortality in septic shock patients: Analysis of national registry data. Crit Care Med 2022; 50:e351-e360
    1. Psaty BM, Siscovick DS: Minimizing bias due to confounding by indication in comparative effectiveness research: The importance of restriction. JAMA 2010; 304:897–898
    1. Sjoding MW, Luo K, Miller MA, et al.: When do confounding by indication and inadequate risk adjustment bias critical care studies? A simulation study. Crit Care 2015; 19:195
    1. Nguyen TL, Collins GS, Spence J, et al.: Double-adjustment in propensity score matching analysis: Choosing a threshold for considering residual imbalance. BMC Med Res Methodol 2017; 17:78
    1. Permpikul C, Tongyoo S, Viarasilpa T, et al.: Early use of norepinephrine in septic shock resuscitation (CENSER). A randomized trial. Am J Respir Crit Care Med 2019; 199:1097–1105

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