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. 2022 Jun 1;50(6):e611-e612.
doi: 10.1097/CCM.0000000000005516. Epub 2022 May 19.

Wacker et al, Who Conclude That Vitamin C Monotherapy Failed to Significantly Reduce Mortality in Septic Shock Patients: Beware of Potential Confounding Factors!

Affiliations

Wacker et al, Who Conclude That Vitamin C Monotherapy Failed to Significantly Reduce Mortality in Septic Shock Patients: Beware of Potential Confounding Factors!

Patrick M Honore et al. Crit Care Med. .
No abstract available

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Conflict of interest statement

The authors have disclosed that they do not have any potential conflicts of interest.

Comment in

  • The authors reply.
    Reilkoff RA, Proper J, Wacker DA. Reilkoff RA, et al. Crit Care Med. 2022 Jun 1;50(6):e612-e613. doi: 10.1097/CCM.0000000000005544. Epub 2022 May 19. Crit Care Med. 2022. PMID: 35612460 No abstract available.

Dataset described in

References

    1. Wacker DA, Burton SL, Berger JP, et al.: Evaluating vitamin C in septic shock: A randomized controlled trial of vitamin C monotherapy. Crit Care Med 2022; 50:e458-e467
    1. Morena M, Cristol JP, Bosc JY, et al.: Convective and diffusive losses of vitamin C during haemodiafiltration session: A contributive factor to oxidative stress in haemodialysis patients. Nephrol Dial Transplant 2002; 17:422–427
    1. Fehrman-Ekholm I, Lotsander A, Logan K, et al.: Concentrations of vitamin C, vitamin B12 and folic acid in patients treated with hemodialysis and on-line hemodiafiltration or hemofiltration. Scand J Urol Nephrol 2008; 42:74–80
    1. Story DA, Ronco C, Bellomo R: Trace element and vitamin concentrations and losses in critically ill patients treated with continuous venovenous hemofiltration. Crit Care Med 1999; 27:220–223
    1. Kamel AY, Dave NJ, Zhao VM, et al.: Micronutrient alterations during continuous renal replacement therapy in critically ill adults: A retrospective study. Nutr Clin Pract 2018; 33:439–446