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Comment
. 2022 Jun 1;50(6):e612-e613.
doi: 10.1097/CCM.0000000000005544. Epub 2022 May 19.

The authors reply

Ronald A Reilkoff  1 , Jennifer Proper  2 , David A Wacker  1
Affiliations
Comment

The authors reply

Ronald A Reilkoff et al. Crit Care Med. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

Drs. Reilkoff and Wacker disclosed the off-label product use of vitamin C use in septic shock as an adjuvant therapy. Dr. Proper has disclosed that she does not have any potential conflicts of interest.

Comment on

References

    1. Honore PM, Redant S, Djimafo P, et al.: Wacker et al, Who Conclude That Vitamin C Monotherapy Failed to Significantly Reduce Mortality in Septic Shock Patients: Beware of Potential Confounding Factors! Crit Care Med 2022; 50:e611–e612
    1. Wacker DA, Burton SL, Berger JP, et al.: Evaluating vitamin C in septic shock: A randomized controlled trial of vitamin C monotherapy. Crit Care Med 2022; 50:e458-e467
    1. Kamel AY, Dave NJ, Zhao VM, et al.: Micronutrient alterations during continuous renal replacement therapy in critically ill adults: A retrospective study. Nutr Clin Pract 2018; 33:439–446
    1. Marik PE, Khangoora V, Rivera R, et al.: Hydrocortisone, vitamin C, and thiamine for the treatment of severe sepsis and septic shock: A retrospective before-after study. Chest 2017; 151:1229–1238
    1. Hwang SY, Ryoo SM, Park JE, et al.; Korean Shock Society (KoSS): Combination therapy of vitamin C and thiamine for septic shock: A multi-centre, double-blinded randomized, controlled study. Intensive Care Med 2020; 46:2015–2025

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