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. 2022 Jun 23;11(4):e220055.
doi: 10.1530/ETJ-22-0055. Print 2022 Aug 1.

Usefulness of thyroid function assessment in infants born to mothers with thyroid dysfunction during pregnancy

Zohar Steinberg Ben-Zeev  1 , Marina Peniakov  2 , Clari Felszer  2 , Scott A Weiner  2 , Avishay Lahad  1 , Shlomo Almashanu  3 , Yardena Tenenbaum Rakover  4   5
Affiliations

Usefulness of thyroid function assessment in infants born to mothers with thyroid dysfunction during pregnancy

Zohar Steinberg Ben-Zeev et al. Eur Thyroid J. .

Abstract

Introduction: Maternal thyroid disease is considered as a risk factor for abnormal thyroid function at birth, as well as for long-term morbidity in offspring. The potential harmful effects on the neonate had led to the clinical practice of thyroid function assessment in infants born to mothers with thyroid disease during pregnancy. In this study, we evaluated the usefulness of routine thyroid function tests for every newborn of a mother with thyroid dysfunction.

Methods: Data were collected retrospectively from the medical files of mothers diagnosed with thyroid disease and their infants (496 mother-neonate pairs). All mothers with diagnosed thyroid disease who gave birth in the years 2016-2019 at our medical center were included.

Results: Hypothyroidism was the most common maternal diagnosis (91.4%), among which 48.7% had Hashimoto's thyroiditis. Hyperthyroidism was diagnosed in 8.6% of the cohort - 71.6% of them with Graves' disease. None of the newborns was diagnosed with congenital hypothyroidism in the screening program. Thyroid-stimulating hormone was >10 mIU/L in 14.6% and >20 mUI/L in 2.2%; all had free thyroxine within normal range. Serum thyroid function test identified four infants with thyroid disease; two had congenital hypothyroidism not related to maternal thyroid disease, one had transient familial congenital hypothyroidism and one had neonatal Graves' disease.

Conclusions: Thyroid function testing for all newborns of mothers with thyroid dysfunction seems redundant. However, in cases of congenital hypothyroidism in siblings, thyroid function test, in addition to newborn thyroid screening, is recommended, and more careful follow-up is indicated. In maternal Graves' disease, thyroid function test on days 2-3 of life is recommended.

Keywords: Graves’ disease; Hashimoto’s thyroiditis; congenital hypothyroidism (CH); subclinical hypothyroidism (SCH); thyroid function tests (TFT).

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References

    1. Negro R, Westman JH. Thyroid disease in pregnancy. Best Practice and Research: Clinical Endocrinology and Metabolism 201125927–943. (10.1016/j.beem.2011.07.010) - DOI - PubMed
    1. Korevaar TIM, Medici M, Visser TJ, Peeters RP. Thyroid disease in pregnancy: new insights in diagnosis and clinical management. Nature Reviews: Endocrinology 201713610–622. (10.1038/nrendo.2017.93) - DOI - PubMed
    1. Ozdemir H, Akman I, Coskun S, Demirel U, Turan S, Bereket A, Bilgen H, Ozek E. Maternal thyroid dysfunction and neonatal thyroid problems. International Journal of Endocrinology 20132013 987843. (10.1155/2013/987843) - DOI - PMC - PubMed
    1. Wikner BN, Sparre LS, Stiller COS, Källén B, Asker C. Maternal use of thyroid hormones in pregnancy and neonatal outcome. Acta Obstetricia et Gynecologica Scandinavica 200887617–627. (10.1080/00016340802075103) - DOI - PubMed
    1. Pop VJ, Brouwers EP, Vader HL, Vulsma T, Van Baar AL, De Vijlder JJ. Maternal hypothyroxinaemia during early pregnancy and subsequent child development: a 3-year follow-up study. Clinical Endocrinology 200359282–288. (10.1046/j.1365-2265.2003.01822.x) - DOI - PubMed