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. 2022 May 25;12(1):8820.
doi: 10.1038/s41598-022-13027-1.

Time to pregnancy in women with previous ectopic pregnancy undergoing in vitro fertilization treatment: a retrospective cohort study

Yamei Xue  1 , Fuxing Zhang  1 , Haocheng Zhang  1 , Songying Zhang  2
Affiliations

Time to pregnancy in women with previous ectopic pregnancy undergoing in vitro fertilization treatment: a retrospective cohort study

Yamei Xue et al. Sci Rep. .

Abstract

We aimed to investigate the difference in the time to pregnancy (TTP) between women with previous ectopic pregnancy (EP) and control women following in vitro fertilization (IVF) treatment and the association between TTP and the number of oocytes retrieved and embryos available. A retrospective study involving 1097 women, 547 of which had previous EP and 550 were control women whose previous pregnancy were abortion, was conducted. Women in the EP group had significantly longer median TTP than those in the control group (36; range, 12-252 vs 28; range, 12-220; P = 0.019). For women with previous EP, > 48 months TTP was most likely associated with low numbers of oocytes retrieved and embryos available compared to TTP of ≤ 24 months or 25-48 months, and women with younger age had a shorter TTP, higher numbers of oocytes retrieved and embryos available. A Cox proportional hazards model showed that maternal age was significantly related to the pregnancy over the TTP (adjusted hazard ratio, 0.934; P < 0.001). In conclusion, women with previous EP have a significantly increased TTP than control women with previous abortion. For women with previous EP, TTP is negatively associated with the numbers of oocytes retrieved and embryos available.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Kaplan–Meier curves for time to pregnancy in women with EP and the control. Log-rank (Mantel–Cox) comparison: P < 0.001.
Figure 2
Figure 2
Kaplan–Meier curves for time to pregnancy in women with previous EP stratified by the maternal age. Log-rank (Mantel–Cox) comparison: P < 0.001.
See this image and copyright information in PMC

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