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. 2022 May 9:9:880796.
doi: 10.3389/fmed.2022.880796. eCollection 2022.

Impact of COVID-19 In-hospital Mortality in Chagas Disease Patients

Gilberto Marcelo Sperandio da Silva  1 , Mauro Felippe Felix Mediano  1 , Michele Ferreira Murgel  1 , Patricia Mello Andrade  1 , Marcelo Teixeira de Holanda  1 , Andréa Rodrigues da Costa  1 , Henrique Horta Veoso  1 , Fernanda de Souza ogueira Sardinha Mendes  1 , Cláudia Maria Valete Rosalino  1 , Andréa Silvestre de Sousa  1 , Fernanda de Souza Nogueira Sardinha Mendes  1 , Cláudia Maria Valete Rosalino  1 , Roberta Olmo Pinheiro  2 , Valdiléa Gonçalves Veloso  1 , Roberto Magalhães Saraiva  1   3 , Alejandro Marcel Hasslocher-Moreno  1   3
Affiliations

Impact of COVID-19 In-hospital Mortality in Chagas Disease Patients

Gilberto Marcelo Sperandio da Silva et al. Front Med (Lausanne). .

Erratum in

  • Corrigendum: Impact of COVID-19 in-hospital mortality in chagas disease patients.
    Sperandio da Silva GM, Mediano MFF, Murgel MF, Andrade PM, de Holanda MT, da Costa AR, Veloso HH, Carneiro FM, Valete Rosalino CM, de Sousa AS, Mendes FSNS, Pinheiro RO, Veloso VG, Saraiva RM, Hasslocher-Moreno AM. Sperandio da Silva GM, et al. Front Med (Lausanne). 2022 Jul 26;9:963805. doi: 10.3389/fmed.2022.963805. eCollection 2022. Front Med (Lausanne). 2022. PMID: 35957851 Free PMC article.

Abstract

The COVID-19 virus infection caused by the new SARS-CoV-2 was first identified in Rio de Janeiro (RJ), Brazil, in March 2020. Until the end of 2021, 504,399 COVID-19 cases were confirmed in RJ, and the total death toll reached 68,347. The Evandro Chagas National Institute of Infectious Diseases from Oswaldo Cruz Foundation (INI-Fiocruz) is a referral center for treatment and research of several infectious diseases, including COVID-19 and Chagas disease (CD). The present study aimed to evaluate the impact of COVID-19 on in-hospital mortality of patients with CD during the COVID-19 pandemic period. This observational, retrospective, longitudinal study evaluated all patients with CD hospitalized at INI-Fiocruz from May 1, 2020, to November 30, 2021. One hundred ten hospitalizations from 81 patients with CD (58% women; 68 ± 11 years) were evaluated. Death was the study's main outcome, which occurred in 20 cases. The mixed-effects logistic regression was performed with the following variables to test whether patients admitted to the hospital with a COVID-19 diagnosis would be more likely to die than those admitted with other diagnoses: admission diagnosis, sex, age, COVID-19 vaccination status, CD clinical classification, and the number of comorbidities. Results from multiple logistic regression analysis showed a higher risk of in-hospital mortality in patients diagnosed with COVID-19 (OR 6.37; 95% CI 1.78-22.86) compared to other causes of admissions. In conclusion, COVID-19 infection had a significant impact on the mortality risk of INI-Fiocruz CD patients, accounting for one-third of deaths overall. COVID-19 presented the highest percentage of death significantly higher than those admitted due to other causes during the COVID-19 pandemic.

Keywords: COVID-19; Chagas disease; SARS-CoV-2; Trypanosoma cruzi; in-hospital mortality.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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