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. 2022 May 9:13:864762.
doi: 10.3389/fimmu.2022.864762. eCollection 2022.

Inflammatory Bowel Disease Therapy: Beyond the Immunome

Claudio Fiocchi  1   2 , Dimitrios Iliopoulos  3
Affiliations

Inflammatory Bowel Disease Therapy: Beyond the Immunome

Claudio Fiocchi et al. Front Immunol. .
No abstract available

Keywords: IBD; complexity; immunome; inflammatory bowel disease; integration; network medicine; systems biology.

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Conflict of interest statement

Author DI was employed by Athos Therapeutics Inc. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Schematic representation of the IBD interactome and its components. Each of the four major pathogenic IBD omes (exposome, genome, microbiome and immunome) is intrinsically complex and influences the composition and behavior of the other omes in a stimulatory (green arrows) and/or inhibitory (red arrows) way. This creates a biological interconnectedness and interdependence among the IBD omes, where the function of the genome is exposome-dependent, the function of the microbiome is exposome and genome-dependent, and the function of the immunome is exposome, genome and microbiome-dependent.
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