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. 2022 Aug 18;60(2):2200102.
doi: 10.1183/13993003.00102-2022. Print 2022 Aug.

Metabolomics in pulmonary medicine: extracting the most from your data

Stacey N Reinke  1 , Romanas Chaleckis  2   3 , Craig E Wheelock  4   3   5
Affiliations

Metabolomics in pulmonary medicine: extracting the most from your data

Stacey N Reinke et al. Eur Respir J. .

Abstract

The metabolome enables unprecedented insight into biochemistry, providing an integrated signature of the genome, transcriptome, proteome and exposome. Measurement requires rigorous protocols combined with specialised data analysis to achieve its promise. https://bit.ly/3yPiYkQ

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Conflict of interest statement

Conflict of interest: None declared.

Figures

FIGURE 1
FIGURE 1
Metabolomics overview illustrating the key components of a metabolomics experimental workflow. While the full complement of the human metabolome remains unknown, estimates range upwards of >1 million compounds. The utility of the metabolome lies in its ability to reflect the integrated metabolic signature of gene and environment (G×E) interactions combined with dietary and lifestyle influences. Measuring the metabolome requires a three-pronged approach that includes rigorous study protocols in combination with dedicated analytical methods and field-specific data analysis. When properly executed, the metabotype can inform clinical diagnosis and treatment as a component of precision medicine approaches. SOPs: standard operating procedures; ID: identification; Dx: diagnosis; Tx: treatment.
See this image and copyright information in PMC

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