Metabolic interactions shape a community's phenotype

Chrats Melkonian¹, Michael F Seidl², Justin J J van der Hooft³, Marjon G J de Vos⁴

Affiliations

¹ Theoretical Biology & Bioinformatics Group, Department of Biology, Utrecht University, 3584CH Utrecht, The Netherlands; Bioinformatics Group, Wageningen University, Droevendaalsesteeg 1, 6708, PB, Wageningen, The Netherlands. Electronic address: c.melkonian@uu.nl.
² Theoretical Biology & Bioinformatics Group, Department of Biology, Utrecht University, 3584CH Utrecht, The Netherlands. Electronic address: m.f.seidl@uu.nl.
³ Bioinformatics Group, Wageningen University, Droevendaalsesteeg 1, 6708, PB, Wageningen, The Netherlands. Electronic address: justin.vanderhooft@wur.nl.
⁴ GELIFES, University of Groningen, 9747AG Groningen, The Netherlands. Electronic address: m.g.j.de.vos@rug.nl.

PMID: 35618541
DOI: 10.1016/j.tim.2022.05.001

Comment

Metabolic interactions shape a community's phenotype

Chrats Melkonian et al. Trends Microbiol. 2022 Jul.

. 2022 Jul;30(7):609-611.

doi: 10.1016/j.tim.2022.05.001. Epub 2022 May 24.

Authors

Chrats Melkonian¹, Michael F Seidl², Justin J J van der Hooft³, Marjon G J de Vos⁴

Affiliations

¹ Theoretical Biology & Bioinformatics Group, Department of Biology, Utrecht University, 3584CH Utrecht, The Netherlands; Bioinformatics Group, Wageningen University, Droevendaalsesteeg 1, 6708, PB, Wageningen, The Netherlands. Electronic address: c.melkonian@uu.nl.
² Theoretical Biology & Bioinformatics Group, Department of Biology, Utrecht University, 3584CH Utrecht, The Netherlands. Electronic address: m.f.seidl@uu.nl.
³ Bioinformatics Group, Wageningen University, Droevendaalsesteeg 1, 6708, PB, Wageningen, The Netherlands. Electronic address: justin.vanderhooft@wur.nl.
⁴ GELIFES, University of Groningen, 9747AG Groningen, The Netherlands. Electronic address: m.g.j.de.vos@rug.nl.

PMID: 35618541
DOI: 10.1016/j.tim.2022.05.001

Abstract

Metabolic interactions between auxotrophs and prototrophs in microbial communities are understudied. Yu et al. showed how intracellular as well as intercellular metabolism affects community fitness in the absence and presence of abiotic stress, that is, drugs.

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Microbial communities form rich extracellular metabolomes that foster metabolic interactions and promote drug tolerance.
Yu JSL, Correia-Melo C, Zorrilla F, Herrera-Dominguez L, Wu MY, Hartl J, Campbell K, Blasche S, Kreidl M, Egger AS, Messner CB, Demichev V, Freiwald A, Mülleder M, Howell M, Berman J, Patil KR, Alam MT, Ralser M. Yu JSL, et al. Nat Microbiol. 2022 Apr;7(4):542-555. doi: 10.1038/s41564-022-01072-5. Epub 2022 Mar 21. Nat Microbiol. 2022. PMID: 35314781 Free PMC article.

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Metabolic interactions shape a community's phenotype

Affiliations

Metabolic interactions shape a community's phenotype

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