Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2022 Dec 1;47(12):1063-1065.
doi: 10.1097/RLU.0000000000004285. Epub 2022 May 27.

Reverse Liver Spleen Uptake on [ 68 Ga]Ga-PSMA-11 PET/CT

Sofiullah Abubakar  1 , Khulood Al Riyami  1 , Anjali Jain  1 , Vipin Jayakrishnan  1 , Naima Tag  2
Affiliations
Case Reports

Reverse Liver Spleen Uptake on [ 68 Ga]Ga-PSMA-11 PET/CT

Sofiullah Abubakar et al. Clin Nucl Med. .

Abstract

An 80-year-old man underwent [ 68 Ga]Ga-PSMA-11 PET/CT for staging of high-risk prostate cancer. Homogeneously increased liver uptake, more than 3-fold the splenic uptake, was seen. There was no hepatic lesion evident on CT. A higher liver to splenic uptake is more typical of some 18 F-labeled PSMA PET/CT but unusual in 68 Ga-labeled PSMA PET/CT scan. Further evaluation revealed a history of impaired renal function, bilateral renal atrophy, relatively decreased renal uptake of [ 68 Ga]Ga-PSMA-11, and prominent bowel activity. We concluded that impaired renal function and subsequent poor excretion resulted in increased hepatic excretion, hence the unusual increased homogeneous hepatic uptake.

PubMed Disclaimer

Conflict of interest statement

Conflicts of interest and sources of funding: none declared.

References

    1. Afshar-Oromieh A, Malcher A, Eder M, et al. PET imaging with a [ 68 Ga]gallium-labelled PSMA ligand for the diagnosis of prostate cancer: biodistribution in humans and first evaluation of tumour lesions. Eur J Nucl Med Mol Imaging . 2013;40:486–495.
    1. Giesel FL, Hadaschik B, Cardinale J, et al. F-18 labelled PSMA-1007: biodistribution, radiation dosimetry and histopathological validation of tumor lesions in prostate cancer patients. Eur J Nucl Med Mol Imaging . 2017;44:678–688.
    1. Ferreira G, Iravani A, Hofman MS, et al. Intra-individual comparison of 68 Ga-PSMA-11 and 18 F-DCFPyL normal-organ biodistribution. Cancer Imaging . 2019;19:23.
    1. Demirci E, Sahin OE, Ocak M, et al. Normal distribution pattern and physiological variants of 68 Ga-PSMA-11 PET/CT imaging. Nucl Med Commun . 2016;37:1169–1179.
    1. Prasad V, Steffen IG, Diederichs G, et al. Biodistribution of [(68)Ga]PSMA-HBED-CC in patients with prostate cancer: characterization of uptake in normal organs and tumour lesions. Mol Imaging Biol . 2016;18:428–436.

Publication types