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. 2022 Dec;42(12):2351-2353.
doi: 10.1177/0271678X221104868. Epub 2022 May 26.

Point/counterpoint: We should take the direction of blood pressure change into consideration for dynamic cerebral autoregulation quantification

Lawrence Labrecque  1   2 , Jonathan D Smirl  3   4   5   6   7   8   9   10 , Yu-Chieh Tzeng  11 , Patrice Brassard  1   2
Affiliations

Point/counterpoint: We should take the direction of blood pressure change into consideration for dynamic cerebral autoregulation quantification

Lawrence Labrecque et al. J Cereb Blood Flow Metab. 2022 Dec.

Abstract

Accumulating evidence suggests asymmetrical responses of cerebral blood flow during large transient changes in mean arterial pressure. Specifically, the augmentation in cerebral blood flow is attenuated when mean arterial pressure acutely increases, compared with declines in cerebral blood flow when mean arterial pressure acutely decreases. However, common analytical tools to quantify dynamic cerebral autoregulation assume autoregulatory responses to be symmetric, which does not seem to be the case. Herein, we provide the rationale supporting the notion we need to consider the directional sensitivity of large and transient mean arterial pressure changes when characterizing dynamic cerebral autoregulation.

Keywords: Asymmetry; cerebral pressure-flow relationship; directional sensitivity; dynamic cerebral autoregulation; mean arterial pressure.

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Conflict of interest statement

The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

References

    1. Tzeng Y-C, Willie CK, Atkinson G, et al. Cerebrovascular regulation during transient hypotension and hypertension in humans. Hypertension 2010; 56: 268–273. - PubMed
    1. Brassard P, Ferland-Dutil H, Smirl JD, et al. Evidence for hysteresis in the cerebral pressure-flow relationship in healthy men. AJP Heart Circ Physiol 2017; 312: H701–H704. - PubMed
    1. Labrecque L, Smirl JD, Brassard P. Utilization of the repeated squat-stand model for studying the directional sensitivity of the cerebral pressure-flow relationship. J Appl Physiol (1985) 2021; 131: 927–936. - PubMed
    1. Labrecque L, Burma JS, Roy M-A, et al. Reproducibility and diurnal variation of the directional sensitivity of the cerebral pressure-flow relationship in men and women. J Appl Physiol 2022; 132: 154–166. - PubMed
    1. Panerai RB, Barnes SC, Nath M, et al. Directional sensitivity of dynamic cerebral autoregulation in squat-stand maneuvers. AJP Regul Integr Comp Physiol 2018; 315: R730–R740. - PubMed

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