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. 2022 May 10:9:851005.
doi: 10.3389/fnut.2022.851005. eCollection 2022.

The Relationship Between Vitamin D and Postoperative Atrial Fibrillation: A Prospective Cohort Study

Amelie H Ohlrogge  1   2 , Jan Brederecke  1 , Francisco M Ojeda  1 , Simon Pecha  2   3 , Christin S Börschel  1   2 , Lenard Conradi  3 , Vanessa Rimkus  1 , Stefan Blankenberg  1   2 , Tanja Zeller  1   2   4 , Renate B Schnabel  1   2
Affiliations

The Relationship Between Vitamin D and Postoperative Atrial Fibrillation: A Prospective Cohort Study

Amelie H Ohlrogge et al. Front Nutr. .

Abstract

Background and aims: The relationship between postoperative atrial fibrillation (POAF) and 25-hydroxyvitamin D [25(OH)D] concentration as well as vitamin D supplementation has been discussed controversially. The relation of pre-operative vitamin D status and POAF remains unclear.

Methods and results: We analysed the risk of POAF in a prospective, observational cohort study of n = 201 patients undergoing coronary artery bypass graft surgery (CABG) with 25(OH)D concentration. The median age was 66.6 years, 15.4% were women. The median (25th/75th percentile) vitamin D concentration at baseline was 17.7 (12.6/23.7) ng/ml. During follow-up we observed 48 cases of POAF. In age, sex, and creatinine-adjusted analyses, 25(OH)D was associated with an increased risk of POAF, though with borderline statistical significance [odds ratio (OR) 1.85, 95% confidence interval (CI) 0.87-3.92, p-value 0.107], in further risk factor-adjusted analyses the results remained stable (OR 1.99, 95% CI 0.90-4.39, p-value 0.087). The subgroup with vitamin D supplementation at baseline showed an increased risk of POAF (OR 5.03, 95% CI 1.13-22.33, p-value 0.034).

Conclusion: In our contemporary mid-European cohort, higher 25(OH)D concentration did not show a benefit for POAF in CABG patients and may even be harmful, though with borderline statistical significance. Our data are in line with a recent randomised study in community-based adults and call for further research to determine both, the clinical impact of elevated 25(OH)D concentration and vitamin D supplementation as well as the possible underlying pathophysiological mechanisms.

Keywords: 25-hydroxyvitamin D; atrial fibrillation; postoperative atrial fibrillation; vitamin D; vitamin D supplementation.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Heat map of correlations of biomarkers and covariates. The colour-coded scale is shown below.
FIGURE 2
FIGURE 2
OR-plot showing the odds ratios and 95% confidence intervals for the logistic regression models.
See this image and copyright information in PMC

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