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Case Reports
. 2022 May 23;10(5):e05848.
doi: 10.1002/ccr3.5848. eCollection 2022 May.

Neurosurgery in a patient with severe hemophilia B: an experience using eftrenonacog alfa as perioperative management

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Case Reports

Neurosurgery in a patient with severe hemophilia B: an experience using eftrenonacog alfa as perioperative management

Olga Benitez Hidalgo et al. Clin Case Rep. .

Abstract

Extended half-life FIX (EHL-FIX) concentrates have been developed with the purpose of reducing the frequency of infusions in patients with severe or moderate hemophilia B. We describe the case of a 63-year-old patient with severe hemophilia B (sHB) treated with FIX-Fc fusion protein (rFIXFc) who underwent neurosurgery.

Keywords: anesthesia; haemophilia B; hematology; neuosurgery; pharmacology; rFIX‐Fc.

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Conflict of interest statement

None.

References

    1. Valeri F, Giacchello JA, Dainese C, et al. Extended half‐life rFIX in major surgery—how to improve clinical practice: an intraindividual comparison. Clin Case Rep. 2020;8(3):531‐534. doi: 10.1002/ccr3.2450 - DOI - PMC - PubMed
    1. Hermans C, Apte S, Santagostino E. Invasive procedures in patients with haemophilia: review of low‐dose protocols and experience with extended half‐ life FVIII and FIX concentrates and non‐replacement therapies. Haemophilia. 2021;27(S3):46‐52. doi: 10.1111/hae.13978 - DOI - PubMed
    1. Ar MC, Balkan C, Kavaklı K. Extended half‐life coagulation factors: a new era in the management of hemophilia patients. Turk J Haematol. 2019;36(3):141‐154. doi: 10.4274/tjh.galenos.2019.2018.0393 - DOI - PMC - PubMed
    1. Powell JS, Apte S, Chambost H, et al. Long‐acting recombinant factor IX Fc fusion protein (rFIXFc) for perioperative management of subjects with haemophilia B in the phase 3 B‐LONG study. Br J Haematol. 2015;168(1):124‐134. - PubMed
    1. Powell JS, Pasi KJ, Ragni MV, et al. Phase 3 study of recombinant factor IXFc fusion protein in haemophilia B. N Engl J Med. 2013;369:2313‐2323. doi: 10.1056/NEJMoa1305074 - DOI - PubMed

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