Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2022 May 13:36:37-41.
doi: 10.1016/j.mmcr.2022.05.004. eCollection 2022 Jun.

First detection of Trichophyton indotineae causing tinea corporis in Central Vietnam

Thi Minh Chau Ngo  1 , Phuong Anh Ton Nu  1 , Chi Cao Le  1 , Thi Ngoc Thuy Ha  1 , Thi Bich Thao Do  1 , Giang Tran Thi  1
Affiliations
Case Reports

First detection of Trichophyton indotineae causing tinea corporis in Central Vietnam

Thi Minh Chau Ngo et al. Med Mycol Case Rep. .

Abstract

Trichophyton indotineae, a new species of dermatophytes, has become a significant concern in treating dermatophytosis due to the high level of terbinafine resistance reported in this organism. This is the first report of Trichophyton indotineae infection in Central Vietnam. Antifungal susceptibility testing showed that this isolate was susceptible to itraconazole, voriconazole, and terbinafine. Therefore, the patient was successfully treated with oral itraconazole and ketoconazole topical cream.

Keywords: Dermatophytes; Tinea corporis; Trichophyton indotineae; Trichophyton interdigitale.

PubMed Disclaimer

Conflict of interest statement

The authors have no conflict of interest.

Figures

Fig. 1
Fig. 1
A. Patient's leg skin lesions, B. Numerous hyphae in skin sample checking with 20% KOH solution.
Fig. 2
Fig. 2
A and B. Macroscopic colonies morphology, C. Microscopic morphology in Lactophenol cotton blue solution. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)
Fig. 3
Fig. 3
Urease test results of T. interdigitale ATCC 9533, T. rubrum ATCC 28188, and isolate No.10 after 7 days incubation (A), 14 days incubation (B).
Fig. 4
Fig. 4
Tween agar positive result after three weeks.
Fig. 5
Fig. 5
Electrophoretic patterns PCR of T. rubrum ATCC 28188 (T.rub), T. interdigitale ATCC 9533 (T.inte), the control negative (C.neg), and isolate No.10.
Fig. 6
Fig. 6
ITS rDNA region aligned results of our isolate (No.10: 4200625) and reference strains: T. interdigitale LC508732.1 and LC508731.1, T. indotineae LC508728.
See this image and copyright information in PMC

References

    1. Brescini L., Fioriti S., Morroni G., Barchiesi F. Antifungal combinations in dermatophytes. J. Fungi. 2021;7(9):727. doi: 10.3390/jof7090727. - DOI - PMC - PubMed
    1. Zhan P., Liu W. The changing face of dermatophytic infections worldwide. Mycopathologia. 2017;182(1–2):77–86. - PubMed
    1. Nenoff P., Kruger C., Ginter-Hanselmayer G., Tietz H.J. Mycology - an update. Part 1: dermatomycoses: causative agents, epidemiology and pathogenesis. Journal der Deutschen Dermatologischen Gesellschaft = J. German Soc. Dermatol.: JDDG. 2014;12(3):188–210. - PubMed
    1. Kano R., Kimura U., Kakurai M., Hiruma J., Kamata H., Suga Y., et al. Trichophyton indotineae sp. nov.: a new highly terbinafine-resistant anthropophilic dermatophyte species. Mycopathologia. 2020;185(6):947–958. - PubMed
    1. Kano R., Noguchi H., Harada K., Hiruma M. Rapid molecular detection of terbinafine-resistant dermatophytes. Med. Mycol. J. 2021;62(2):41–44. - PubMed

Publication types

LinkOut - more resources