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Review
. 2022 Jun 30;57(2):95-100.
doi: 10.5045/br.2022.2021173. Epub 2022 May 30.

Chronic myeloid leukemia: a type of MPN

Muhammad Ammar Samad  1 , Eman Mahboob  1 , Hussain Mansoor  1
Affiliations
Review

Chronic myeloid leukemia: a type of MPN

Muhammad Ammar Samad et al. Blood Res. .

Abstract

This review article classifies chronic myeloid leukemia (CML) based on cytogenetic analyses and different mutations detected in CML patients. The use of advanced technologies, such as karyotyping, fluorescent in situ hybridization, and comparative genomic hybridization, has allowed us to study CML in detail and observe the different biochemical changes that occur in different CML types. This review also highlights the different types of receptor and signaling pathway mutations that occur in CML.

Keywords: Chronic myeloid leukemia; Cytogenetics; Myeloproliferative neoplasms; Philadelphia chromosome.

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Conflict of interest statement

Authors’ Disclosures of Potential Conflicts of Interest

No potential conflicts of interest relevant to this article were reported.

Figures

Fig. 1
Fig. 1
Translocation of the break-point cluster region (BCR) gene.
Fig. 2
Fig. 2
Gene mutations detected in patients with chronic myelomono-cytic leukemia (CMML).
See this image and copyright information in PMC

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