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. 2022 Jul;19(7):e202200355.
doi: 10.1002/cbdv.202200355. Epub 2022 May 27.

Two New Xanthones from the Twigs of Calophyllum membranaceum and Their Anti-Inflammatory Activities in HESC Cells

Si-Yuan Li  1 , Ya-Hui Mi  1 , Wei Shen  1 , Xiao-Long Hu  1 , Jing Zhang  1 , Fang Nan  1 , Zhe Song  2 , Xiao-Qi Zhang  3 , Wen-Cai Ye  3 , Hao Wang  1
Affiliations

Two New Xanthones from the Twigs of Calophyllum membranaceum and Their Anti-Inflammatory Activities in HESC Cells

Si-Yuan Li et al. Chem Biodivers. 2022 Jul.

Abstract

Two new xanthones, calmemxanthone A (1) and calmemxanthone B (2), along with eleven known compounds were isolated from the dried twigs of Calophyllum membranaceum Gardn. et Champ. The structures of compounds 1 and 2 were established by analysis of spectra and mass spectrometry data. The absolute configuration of compound 1 was confirmed by electronic circular dichroism (ECD) spectral analysis. The anti-inflammation action of these compounds were evaluated on lipopolysaccharide (LPS)-induced inflammatory damage to human endometrial stromal cells (HESCs), and the structure-activities of 1-13 were also discussed. Compound 10 presented the anti-inflammation action with an IC50 value of 20.3 μM, that might be relevant to the regulation of NF-κB signaling pathway via the suppression of TRIF, IKKα, and IκBα.

Keywords: Calophyllum membranaceum; anti-inflammation; endometriosis; xanthone.

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