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Review
. 2022 May 18;29(5):3668-3697.
doi: 10.3390/curroncol29050295.

De-Escalation Strategies for Human Papillomavirus-Associated Oropharyngeal Squamous Cell Carcinoma-Where Are We Now?

Jennifer A Silver  1   2 , Sena Turkdogan  1   2 , Catherine F Roy  1   2 , Thavakumar Subramaniam  1   2 , Melissa Henry  2   3   4   5 , Nader Sadeghi  1   2   6
Affiliations
Review

De-Escalation Strategies for Human Papillomavirus-Associated Oropharyngeal Squamous Cell Carcinoma-Where Are We Now?

Jennifer A Silver et al. Curr Oncol. .

Abstract

The prevalence of oropharyngeal squamous cell carcinoma has been increasing in North America due to human papillomavirus-associated disease. It is molecularly distinct and differs from other head and neck cancers due to the young population and high survival rate. The treatment regimens currently in place cause significant long-term toxicities. Studies have transitioned from mortality-based outcomes to patient-reported outcomes assessing quality of life. There are many completed and ongoing trials investigating alternative therapy regimens or de-escalation strategies to minimize the negative secondary effects while maintaining overall survival and disease-free survival. The goal of this review is to discuss the most recent advancements within the field while summarizing and reviewing the available evidence.

Keywords: de-escalation; human papillomavirus; oropharyngeal squamous cell carcinoma; transoral surgery.

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Conflict of interest statement

The authors declare no conflict of interest.

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