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Case Reports
. 2022 Oct;481(4):659-663.
doi: 10.1007/s00428-022-03348-x. Epub 2022 May 27.

CD2-negative lymphoma-associated T-cells: a potential mechanism of immune-evasion in diffuse large B-cell lymphoma

Anindita Ghosh #  1 , Mario L Marques-Piubelli #  2 , Xiaoqiong Wang  3 , Tiffany G Sheu  4 , Joanne Cheng  3 , Khaja Khan  2 , Wei Lu  2 , John Manning  3 , Guilin Tang  3 , Luisa M Solis  2 , Francisco Vega  5
Affiliations
Case Reports

CD2-negative lymphoma-associated T-cells: a potential mechanism of immune-evasion in diffuse large B-cell lymphoma

Anindita Ghosh et al. Virchows Arch. 2022 Oct.

Abstract

CD2 is a costimulatory protein expressed in all mature T/NK-cells, in particular memory T-cells. CD58 (or LFA-3) is the receptor for CD2 and is ubiquitously expressed. CD2-CD58 interaction has key functions in T-cell activation and organization of the immunological synapse between T- and antigen-presenting cells. Cancer cells have developed multiple mechanisms to evade immune surveillance. Loss of CD58 expression is one frequently reported in diffuse large B-cell lymphomas (DLBCL). On the other hand, in non-hematological neoplasms, tumor infiltrating lymphocytes (TILs) with reduced expression of CD2 have been associated with defective cytotoxicity and T-cell exhaustion. Here, we reported a case of DLBCL involving the jejunal mucosa associated with a rim of cytotoxic reactive T-cells with features of immune evasion (CD2- and TCR-) and T-cell exhaustion (PD1 + high). This case likely exemplifies a previously unrecognized immune evasion mechanism in lymphoma involving a decreased CD2 expression in the lymphoma-associated T-cells.

Keywords: CD2; CD58; Diffuse large B-cell lymphoma; Immune evasion; Lymphoma-associated lymphoid cells.

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References

    1. Challa-Malladi M, Lieu YK, Califano O, Holmes AB, Bhagat G, Murty VV, Dominguez-Sola D, Pasqualucci L, Dalla-Favera R (2011) Combined genetic inactivation of beta2-Microglobulin and CD58 reveals frequent escape from immune recognition in diffuse large B cell lymphoma. Cancer Cell 20:728–740. https://doi.org/10.1016/j.ccr.2011.11.006 - DOI - PubMed - PMC
    1. Demetriou P, Abu-Shah E, Valvo S, McCuaig S, Mayya V, Kvalvaag A, Starkey T, Korobchevskaya K, Lee LYW, Friedrich M, Mann E, Kutuzov MA, Morotti M, Wietek N, Rada H, Yusuf S, Afrose J, Siokis A, Oxford IBDCI, Meyer-Hermann M, Ahmed AA, Depoil D, Dustin ML (2020) A dynamic CD2-rich compartment at the outer edge of the immunological synapse boosts and integrates signals. Nat Immunol 21:1232–1243. https://doi.org/10.1038/s41590-020-0770-x - DOI - PubMed - PMC
    1. Demetriou P, Abu-Shah E, Valvo S, McCuaig S, Mayya V, Kvalvaag A, Starkey T, Korobchevskaya K, Lee LYW, Friedrich M, Mann E, Kutuzov MA, Morotti M, Wietek N, Rada H, Yusuf S, Afrose J, Siokis A, Oxford IBDCI, Meyer-Hermann M, Ahmed AA, Depoil D, Dustin ML (2021) Author correction: a dynamic CD2-rich compartment at the outer edge of the immunological synapse boosts and integrates signals. Nat Immunol 22:99. https://doi.org/10.1038/s41590-020-00825-w - DOI - PubMed
    1. Dustin ML, Olszowy MW, Holdorf AD, Li J, Bromley S, Desai N, Widder P, Rosenberger F, van der Merwe PA, Allen PM, Shaw AS (1998) A novel adaptor protein orchestrates receptor patterning and cytoskeletal polarity in T-cell contacts. Cell 94:667–677. https://doi.org/10.1016/s0092-8674(00)81608-6 - DOI - PubMed
    1. Koneru M, Monu N, Schaer D, Barletta J, Frey AB (2006) Defective adhesion in tumor infiltrating CD8+ T cells. J Immunol 176:6103–6111. https://doi.org/10.4049/jimmunol.176.10.6103 - DOI - PubMed

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