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Comment
. 2022 May 27;20(5):e3001673.
doi: 10.1371/journal.pbio.3001673. eCollection 2022 May.

Whole-proteome structures shed new light on posttranslational modifications

Robbie P Joosten  1 , Jon Agirre  2
Affiliations
Comment

Whole-proteome structures shed new light on posttranslational modifications

Robbie P Joosten et al. PLoS Biol. .

Abstract

Accurate but protein-only AlphaFold models may show structural fingerprints of likely posttranslational modifications (PTMs). In this issue of PLOS Biology, Bludau and colleagues add a functional context to models by combining them with readily available proteomics results.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Different sequence profiles in exposed and solvent-excluded phosphosites (STY) as recognised by different kinases.
The availability of accurate 3D models now allows for this direct mapping of sequence profiles onto structures and allows estimating their solvent accessibility. Extracted from Fig 3d of Bludau and colleagues [10].
See this image and copyright information in PMC

Comment on

References

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