Genetic determinants of mannose-binding lectin activity predispose to thromboembolic complications in critical COVID-19

Michael Hultström^#^{1

2

3

4}, Robert Frithiof^#¹, Jonathan Grip^#^{5

6}, Linnea Lindelöf^#⁷, Olav Rooijackers^{5

6}, Sara Pigazzini⁸, Mari Niemi⁸, Mattia Cordioli⁸, Lindo Nkambule⁸, Tomislav Maricic⁹, Kristina Nilsson Ekdahl^{7

10}, Bo Nilsson⁷, Miklós Lipcsey^{1

11}, Hugo Zeberg^#^{12

13}, Oskar Eriksson^#¹⁴

Affiliations

¹ Anesthesiology and Intensive Care Medicine, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
² Integrative Physiology, Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden.
³ Department of Epidemiology, McGill University, Montréal, Quebec, Canada.
⁴ Lady Davis Institute of Medical Research, Jewish General Hospital, Montréal, Quebec, Canada.
⁵ Department of Perioperative Medicine and Intensive Care, Karolinska University Hospital, Stockholm, Sweden.
⁶ Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.
⁷ Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
⁸ Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.
⁹ Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany.
¹⁰ Linnaeus Center for Biomaterials Chemistry, Linnaeus University, Kalmar, Sweden.
¹¹ Hedenstierna Laboratory, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
¹² Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany. hugo.zeberg@ki.se.
¹³ Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden. hugo.zeberg@ki.se.
¹⁴ Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden. oskar.eriksson@igp.uu.se.

^# Contributed equally.

PMID: 35624204
DOI: 10.1038/s41590-022-01227-w

Comment

Genetic determinants of mannose-binding lectin activity predispose to thromboembolic complications in critical COVID-19

Michael Hultström et al. Nat Immunol. 2022 Jun.

. 2022 Jun;23(6):861-864.

doi: 10.1038/s41590-022-01227-w. Epub 2022 May 27.

Authors

Affiliations

¹ Anesthesiology and Intensive Care Medicine, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
² Integrative Physiology, Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden.
³ Department of Epidemiology, McGill University, Montréal, Quebec, Canada.
⁴ Lady Davis Institute of Medical Research, Jewish General Hospital, Montréal, Quebec, Canada.
⁵ Department of Perioperative Medicine and Intensive Care, Karolinska University Hospital, Stockholm, Sweden.
⁶ Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.
⁷ Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
⁸ Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.
⁹ Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany.
¹⁰ Linnaeus Center for Biomaterials Chemistry, Linnaeus University, Kalmar, Sweden.
¹¹ Hedenstierna Laboratory, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
¹² Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany. hugo.zeberg@ki.se.
¹³ Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden. hugo.zeberg@ki.se.
¹⁴ Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden. oskar.eriksson@igp.uu.se.

^# Contributed equally.

PMID: 35624204
DOI: 10.1038/s41590-022-01227-w

No abstract available

PubMed Disclaimer

Comment in

Reply to: Hultström et al., Genetic determinants of mannose-binding lectin activity predispose to thromboembolic complications in critical COVID-19. Mannose-binding lectin genetics in COVID-19.
Asselta R, Paraboschi EM, Stravalaci M, Invernizzi P, Bonfanti P, Biondi A, Pagani I, Pedotti M, Doni A, Scavello F, Mapelli SN, Sironi M, Perucchini C, Varani L, Matkovic M, Cavalli A, Cesana D, Gallina P, Pedemonte N, Capurro V, Clementi N, Mancini N, Bayarri-Olmos R, Garred P, Rappuoli R, Duga S, Bottazzi B, Uguccioni M, Vicenzi E, Mantovani A, Garlanda C. Asselta R, et al. Nat Immunol. 2022 Jun;23(6):865-867. doi: 10.1038/s41590-022-01228-9. Epub 2022 May 27. Nat Immunol. 2022. PMID: 35624207 No abstract available.

Comment on

Recognition and inhibition of SARS-CoV-2 by humoral innate immunity pattern recognition molecules.
Stravalaci M, Pagani I, Paraboschi EM, Pedotti M, Doni A, Scavello F, Mapelli SN, Sironi M, Perucchini C, Varani L, Matkovic M, Cavalli A, Cesana D, Gallina P, Pedemonte N, Capurro V, Clementi N, Mancini N, Invernizzi P, Bayarri-Olmos R, Garred P, Rappuoli R, Duga S, Bottazzi B, Uguccioni M, Asselta R, Vicenzi E, Mantovani A, Garlanda C. Stravalaci M, et al. Nat Immunol. 2022 Feb;23(2):275-286. doi: 10.1038/s41590-021-01114-w. Epub 2022 Jan 31. Nat Immunol. 2022. PMID: 35102342

References

1. Stravalaci, M. et al. Recognition and inhibition of SARS-CoV-2 by humoral innate immunity pattern recognition molecules. Nat. Immunol. 23, 275–286 (2022). - DOI - PubMed
1. Niemi, M. E. K. et al. Mapping the human genetic architecture of COVID-19. Nature 600, 472–477 (2021). - DOI
1. SweCovid. The genetic predisposition to severe COVID-19. Genomic analysis of critically ill COVI-19 patients in Sweden. https://swecovid.org
1. Garred, P. et al. A journey through the lectin pathway of complement—MBL and beyond. Immunol. Rev. 274, 74–97 (2016). - DOI - PubMed
1. Madsen, H. O. et al. Interplay between promoter and structural gene variants control basal serum level of mannan-binding protein. J. Immunol. 155, 3013–3020 (1995). - PubMed

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Genetic determinants of mannose-binding lectin activity predispose to thromboembolic complications in critical COVID-19

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Genetic determinants of mannose-binding lectin activity predispose to thromboembolic complications in critical COVID-19

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