Reply to: Hultström et al., Genetic determinants of mannose-binding lectin activity predispose to thromboembolic complications in critical COVID-19. Mannose-binding lectin genetics in COVID-19

Rosanna Asselta^#^{1

2}, Elvezia Maria Paraboschi^#^{1

2}, Matteo Stravalaci^{1

2}, Pietro Invernizzi^{3

4}, Paolo Bonfanti⁵, Andrea Biondi⁶, Isabel Pagani⁷, Mattia Pedotti⁸, Andrea Doni¹, Francesco Scavello¹, Sarah N Mapelli¹, Marina Sironi¹, Chiara Perucchini¹, Luca Varani⁸, Milos Matkovic⁸, Andrea Cavalli^{8

9}, Daniela Cesana¹⁰, Pierangela Gallina¹⁰, Nicoletta Pedemonte¹¹, Valeria Capurro¹¹, Nicola Clementi¹², Nicasio Mancini¹², Rafael Bayarri-Olmos¹³, Peter Garred¹³, Rino Rappuoli^{14

15}, Stefano Duga^{1

2}, Barbara Bottazzi¹, Mariagrazia Uguccioni^{2

8}, Elisa Vicenzi⁷, Alberto Mantovani^{16

17

18}, Cecilia Garlanda^{19

20}

Affiliations

¹ IRCCS Humanitas Research Hospital, Milan, Italy.
² Department of Biomedical Sciences, Humanitas University, Milan, Italy.
³ Division of Gastroenterology, Center for Autoimmune Liver Diseases, Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.
⁴ European Reference Network on Hepatological Diseases, San Gerardo Hospital, Monza, Italy.
⁵ Department of Infectious Diseases, San Gerardo Hospital, University of Milano-Bicocca, Monza, Italy.
⁶ Pediatric Department and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-San Gerardo Hospital, Monza, Italy.
⁷ Viral Pathogenesis and Biosafety Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
⁸ Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland.
⁹ Swiss Institute of Bioinformatics, Lausanne, Switzerland.
¹⁰ San Raffaele Telethon Institute for Gene Therapy, IRCCS, San Raffaele Scientific Institute, Milan, Italy.
¹¹ UOC Genetica Medica, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
¹² Laboratory of Microbiology and Virology, IRCCS Scientific Institute and Vita-Salute San Raffaele University, Milan, Italy.
¹³ Laboratory of Molecular Medicine, Department of Clinical Immunology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
¹⁴ Monoclonal Antibody Discovery Lab, Fondazione Toscana Life Sciences, Siena, Italy.
¹⁵ Faculty of Medicine, Imperial College London, London, UK.
¹⁶ IRCCS Humanitas Research Hospital, Milan, Italy. alberto.mantovani@humanitasresearch.it.
¹⁷ Department of Biomedical Sciences, Humanitas University, Milan, Italy. alberto.mantovani@humanitasresearch.it.
¹⁸ The William Harvey Research Institute, Queen Mary University of London, London, UK. alberto.mantovani@humanitasresearch.it.
¹⁹ IRCCS Humanitas Research Hospital, Milan, Italy. cecilia.garlanda@humanitasresearch.it.
²⁰ Department of Biomedical Sciences, Humanitas University, Milan, Italy. cecilia.garlanda@humanitasresearch.it.

^# Contributed equally.

PMID: 35624207
DOI: 10.1038/s41590-022-01228-9

Comment

Reply to: Hultström et al., Genetic determinants of mannose-binding lectin activity predispose to thromboembolic complications in critical COVID-19. Mannose-binding lectin genetics in COVID-19

Rosanna Asselta et al. Nat Immunol. 2022 Jun.

. 2022 Jun;23(6):865-867.

doi: 10.1038/s41590-022-01228-9. Epub 2022 May 27.

Authors

Affiliations

¹ IRCCS Humanitas Research Hospital, Milan, Italy.
² Department of Biomedical Sciences, Humanitas University, Milan, Italy.
³ Division of Gastroenterology, Center for Autoimmune Liver Diseases, Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.
⁴ European Reference Network on Hepatological Diseases, San Gerardo Hospital, Monza, Italy.
⁵ Department of Infectious Diseases, San Gerardo Hospital, University of Milano-Bicocca, Monza, Italy.
⁶ Pediatric Department and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-San Gerardo Hospital, Monza, Italy.
⁷ Viral Pathogenesis and Biosafety Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
⁸ Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland.
⁹ Swiss Institute of Bioinformatics, Lausanne, Switzerland.
¹⁰ San Raffaele Telethon Institute for Gene Therapy, IRCCS, San Raffaele Scientific Institute, Milan, Italy.
¹¹ UOC Genetica Medica, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
¹² Laboratory of Microbiology and Virology, IRCCS Scientific Institute and Vita-Salute San Raffaele University, Milan, Italy.
¹³ Laboratory of Molecular Medicine, Department of Clinical Immunology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
¹⁴ Monoclonal Antibody Discovery Lab, Fondazione Toscana Life Sciences, Siena, Italy.
¹⁵ Faculty of Medicine, Imperial College London, London, UK.
¹⁶ IRCCS Humanitas Research Hospital, Milan, Italy. alberto.mantovani@humanitasresearch.it.
¹⁷ Department of Biomedical Sciences, Humanitas University, Milan, Italy. alberto.mantovani@humanitasresearch.it.
¹⁸ The William Harvey Research Institute, Queen Mary University of London, London, UK. alberto.mantovani@humanitasresearch.it.
¹⁹ IRCCS Humanitas Research Hospital, Milan, Italy. cecilia.garlanda@humanitasresearch.it.
²⁰ Department of Biomedical Sciences, Humanitas University, Milan, Italy. cecilia.garlanda@humanitasresearch.it.

^# Contributed equally.

PMID: 35624207
DOI: 10.1038/s41590-022-01228-9

No abstract available

PubMed Disclaimer

Comment on

Recognition and inhibition of SARS-CoV-2 by humoral innate immunity pattern recognition molecules.
Stravalaci M, Pagani I, Paraboschi EM, Pedotti M, Doni A, Scavello F, Mapelli SN, Sironi M, Perucchini C, Varani L, Matkovic M, Cavalli A, Cesana D, Gallina P, Pedemonte N, Capurro V, Clementi N, Mancini N, Invernizzi P, Bayarri-Olmos R, Garred P, Rappuoli R, Duga S, Bottazzi B, Uguccioni M, Asselta R, Vicenzi E, Mantovani A, Garlanda C. Stravalaci M, et al. Nat Immunol. 2022 Feb;23(2):275-286. doi: 10.1038/s41590-021-01114-w. Epub 2022 Jan 31. Nat Immunol. 2022. PMID: 35102342
Genetic determinants of mannose-binding lectin activity predispose to thromboembolic complications in critical COVID-19.
Hultström M, Frithiof R, Grip J, Lindelöf L, Rooijackers O, Pigazzini S, Niemi M, Cordioli M, Nkambule L, Maricic T, Ekdahl KN, Nilsson B, Lipcsey M, Zeberg H, Eriksson O. Hultström M, et al. Nat Immunol. 2022 Jun;23(6):861-864. doi: 10.1038/s41590-022-01227-w. Epub 2022 May 27. Nat Immunol. 2022. PMID: 35624204 No abstract available.

References

1. Stravalaci, M. et al. Recognition and inhibition of SARS-CoV-2 by humoral innate immunity pattern recognition molecules. Nat. Immunol. 23, 275–286 (2022). - DOI
1. Hultström, M. et al. Genetic determinants of mannose-binding lectin activity predispose to thromboembolic complications in critical COVID-19. Nat. Immunol. https://doi.org/10.1038/s41590-022-01227-w (2022).
1. COVID-19 Host Genetics Initiative. Mapping the human genetic architecture of COVID-19. Nature 600, 472–477 (2021). - DOI
1. Madsen, H. O. et al. Interplay between promoter and structural gene variants control basal serum level of mannan-binding protein. J. Immunol. 155, 3013–3020 (1995). - PubMed
1. Lempp, F. A. et al. Lectins enhance SARS-CoV-2 infection and influence neutralizing antibodies. Nature 598, 342–347 (2021). - DOI

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Reply to: Hultström et al., Genetic determinants of mannose-binding lectin activity predispose to thromboembolic complications in critical COVID-19. Mannose-binding lectin genetics in COVID-19

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Reply to: Hultström et al., Genetic determinants of mannose-binding lectin activity predispose to thromboembolic complications in critical COVID-19. Mannose-binding lectin genetics in COVID-19

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