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Review
. 2022 May 27;21(1):84.
doi: 10.1186/s12933-022-01526-4.

Sodium‑glucose co-transporter‑2 inhibitors in the treatment of diabetes with heart failure

Bo Liang  1 , Ning Gu  2
Affiliations
Review

Sodium‑glucose co-transporter‑2 inhibitors in the treatment of diabetes with heart failure

Bo Liang et al. Cardiovasc Diabetol. .

Abstract

2022 AHA/ACC/HFSA guideline for the management of heart failure, which is valuable for clinical decision-making, was recently released. This guideline recommended patients with heart failure with type 2 diabetes sodium‑glucose co-transporter‑2 inhibitors for the management of hyperglycemia and to reduce heart failure-related morbidity and mortality (Class 1, Level A). It is important to note that the source of evidence based on this recommendation is from EMPEROR-Reduced, DAPA-HF, and DECLARE-TIMI 58 and does not include newly published PRESERVED-HF, CHIEF-HF, and EMPEROR-Preserved. Here we reviewed these important trials in order to provide more clinical references for patients with diabetes and heart failure, especially heart failure with preserved ejection fraction.

Keywords: Diabetes; Heart failure; Sodium‑glucose co-transporter‑2 inhibitors.

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Conflict of interest statement

The authors declare that they have no competing interests.

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