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Review
. 2022 May 11;11(5):942.
doi: 10.3390/antiox11050942.

Metabolism Dysregulation in Retinal Diseases and Related Therapies

Yingying Chen  1   2 , Nathan J Coorey  3 , Meixia Zhang  1   4 , Shaoxue Zeng  2 , Michele C Madigan  2   5 , Xinyuan Zhang  6   7 , Mark C Gillies  2 , Ling Zhu  2 , Ting Zhang  2
Affiliations
Review

Metabolism Dysregulation in Retinal Diseases and Related Therapies

Yingying Chen et al. Antioxidants (Basel). .

Abstract

The human retina, which is part of the central nervous system, has exceptionally high energy demands that requires an efficient metabolism of glucose, lipids, and amino acids. Dysregulation of retinal metabolism disrupts local energy supply and redox balance, contributing to the pathogenesis of diverse retinal diseases, including age-related macular degeneration, diabetic retinopathy, inherited retinal degenerations, and Macular Telangiectasia. A better understanding of the contribution of dysregulated metabolism to retinal diseases may provide better therapeutic targets than we currently have.

Keywords: gene therapy; lipid metabolism; metabolism; retina; retinal diseases.

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Conflict of interest statement

The authors declare no conflict of interest.

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