Peripheral Neuropathies Derived from COVID-19: New Perspectives for Treatment

doi:10.3390/biomedicines10051051

Review

. 2022 May 2;10(5):1051.

doi: 10.3390/biomedicines10051051.

Peripheral Neuropathies Derived from COVID-19: New Perspectives for Treatment

Alfredo Córdova-Martínez¹, Alberto Caballero-García², Daniel Pérez-Valdecantos¹, Enrique Roche^{3

4

5}, David César Noriega-González⁶

Affiliations

¹ Department of Biochemistry, Molecular Biology and Physiology, Faculty of Health Sciences, GIR Physical Exercise and Aging, University of Valladolid, Campus Duques de Soria, 42004 Soria, Spain.
² Department of Anatomy and Radiology, Faculty of Health Sciences, GIR Physical Exercise and Aging, University of Valladolid, Campus Duques de Soria, 42004 Soria, Spain.
³ Department of Applied Biology-Nutrition, Institute of Bioengineering, University Miguel Hernández, 03202 Elche, Spain.
⁴ Alicante Institute for Health and Biomedical Research (ISABIAL), 03010 Alicante, Spain.
⁵ CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain.
⁶ Department of Surgery, Ophthalmology, Otorhinolaryngology and Physiotherapy, Faculty of Medicine, Hospital Clínico Universitario de Valladolid, 47005 Valladolid, Spain.

PMID: 35625788
PMCID: PMC9138404
DOI: 10.3390/biomedicines10051051

Review

Peripheral Neuropathies Derived from COVID-19: New Perspectives for Treatment

Alfredo Córdova-Martínez et al. Biomedicines. 2022.

. 2022 May 2;10(5):1051.

doi: 10.3390/biomedicines10051051.

Authors

Alfredo Córdova-Martínez¹, Alberto Caballero-García², Daniel Pérez-Valdecantos¹, Enrique Roche^{3

4

5}, David César Noriega-González⁶

Affiliations

¹ Department of Biochemistry, Molecular Biology and Physiology, Faculty of Health Sciences, GIR Physical Exercise and Aging, University of Valladolid, Campus Duques de Soria, 42004 Soria, Spain.
² Department of Anatomy and Radiology, Faculty of Health Sciences, GIR Physical Exercise and Aging, University of Valladolid, Campus Duques de Soria, 42004 Soria, Spain.
³ Department of Applied Biology-Nutrition, Institute of Bioengineering, University Miguel Hernández, 03202 Elche, Spain.
⁴ Alicante Institute for Health and Biomedical Research (ISABIAL), 03010 Alicante, Spain.
⁵ CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain.
⁶ Department of Surgery, Ophthalmology, Otorhinolaryngology and Physiotherapy, Faculty of Medicine, Hospital Clínico Universitario de Valladolid, 47005 Valladolid, Spain.

PMID: 35625788
PMCID: PMC9138404
DOI: 10.3390/biomedicines10051051

Abstract

Peripheral neuropathies constitute a group of disorders affecting the peripheral nervous system. Neuropathies have multiple causes such as infections (i.e., COVID-19), diabetes, and nutritional (low vitamin levels), among others. Many micronutrients, such as vitamins (A, C, D, E, B6, B12, and folate), certain minerals (Fe, Mg, Zn, Se, and Cu), and ω-3 fatty acids have immunomodulatory effects. Therefore, they may play an instrumental role in the treatment of COVID-19 infection. However, many COVID-19 patients can undergo neuropathy. In this context, there is a wealth of information on a variety of first-, second-, and third-line treatment options. This review focuses on the application of nutraceutical strategies in order to improve the symptomatology of neuropathy and neuropathic pain in patients that suffered from COVID-19. Our aim is to provide an alternative vision to traditional medical-pharmacological treatment through nutraceuticals.

Keywords: COVID-19; nutraceuticals; peripheral neuropathy; vitamins; α-lipoic acid.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Cited by

Delayed Surgical Treatment in Patients with Chronic Carpal Tunnel Syndrome Is Still Effective in the Improvement of Hand Function.
Twardowska M, Czarnecki P, Jokiel M, Bręborowicz E, Huber J, Romanowski L. Twardowska M, et al. Medicina (Kaunas). 2023 Jul 31;59(8):1404. doi: 10.3390/medicina59081404. Medicina (Kaunas). 2023. PMID: 37629694 Free PMC article.
Unilateral Compressive Peroneal Neuropathy in Intensive Care Settings During the COVID-19 Pandemic: A Series of Three Cases.
Andiappan K, Nyein Yin K, Zainudin MF. Andiappan K, et al. Cureus. 2024 Jul 30;16(7):e65789. doi: 10.7759/cureus.65789. eCollection 2024 Jul. Cureus. 2024. PMID: 39211702 Free PMC article.
Unveiling the Mysteries of Long COVID Syndrome: Exploring the Distinct Tissue and Organ Pathologies Linked to Prolonged COVID-19 Symptoms.
Sapna F, Deepa F, Sakshi F, Sonam F, Kiran F, Perkash RS, Bendari A, Kumar A, Rizvi Y, Suraksha F, Varrassi G. Sapna F, et al. Cureus. 2023 Sep 2;15(9):e44588. doi: 10.7759/cureus.44588. eCollection 2023 Sep. Cureus. 2023. PMID: 37795061 Free PMC article. Review.
Post-acute sequelae SARS-CoV-2 infection and neuropathic pain: a narrative review of the literature and future directions.
Vu PD, Abdi S. Vu PD, et al. Pain Manag. 2025 Jun;15(6):333-343. doi: 10.1080/17581869.2025.2501521. Epub 2025 May 14. Pain Manag. 2025. PMID: 40366711 Review.
Long COVID, the Brain, Nerves, and Cognitive Function.
Reiss AB, Greene C, Dayaramani C, Rauchman SH, Stecker MM, De Leon J, Pinkhasov A. Reiss AB, et al. Neurol Int. 2023 Jul 6;15(3):821-841. doi: 10.3390/neurolint15030052. Neurol Int. 2023. PMID: 37489358 Free PMC article. Review.

See all "Cited by" articles

References

1. Siao P., Kaku M. A clinician’s approach to peripheral neuropathy. Semin. Neurol. 2019;39:519–530. doi: 10.1055/s-0039-1694747. - DOI - PubMed
1. Head K.A. Peripheral neuropathy: Pathogenic mechanisms and alternative therapies. Altern. Med. Rev. 2006;11:294–329. - PubMed
1. Damayanthi H.D.W.T., Prabani K.I.P. Nutritional determinants and COVID-19 outcomes of older patients with COVID-19: A systematic review. Arch. Gerontol. Geriatr. 2021;95:104411. doi: 10.1016/j.archger.2021.104411. - DOI - PMC - PubMed
1. Jia H. Pulmonary Angiotensin-Converting Enzyme 2 (ACE2) and inflammatory lung disease. Shock. 2016;46:239–248. doi: 10.1097/SHK.0000000000000633. - DOI - PubMed
1. Shakoor H., Feehan J., Al Dhaheri A.S., Ali H.I., Platat C., Ismail L.C., Apostolopoulos V., Stojanovska L. Immune-boosting role of vitamins D, C, E, zinc, selenium and omega-3 fatty acids: Could they help against COVID-19? Maturitas. 2021;143:1–9. doi: 10.1016/j.maturitas.2020.08.003. - DOI - PMC - PubMed

Publication types

Actions

LinkOut - more resources

Full Text Sources

[1] Siao P., Kaku M. A clinician’s approach to peripheral neuropathy. Semin. Neurol. 2019;39:519–530. doi: 10.1055/s-0039-1694747. - DOI - PubMed

[2] Siao P., Kaku M. A clinician’s approach to peripheral neuropathy. Semin. Neurol. 2019;39:519–530. doi: 10.1055/s-0039-1694747. - DOI - PubMed

[3] Head K.A. Peripheral neuropathy: Pathogenic mechanisms and alternative therapies. Altern. Med. Rev. 2006;11:294–329. - PubMed

[4] Head K.A. Peripheral neuropathy: Pathogenic mechanisms and alternative therapies. Altern. Med. Rev. 2006;11:294–329. - PubMed

[5] Damayanthi H.D.W.T., Prabani K.I.P. Nutritional determinants and COVID-19 outcomes of older patients with COVID-19: A systematic review. Arch. Gerontol. Geriatr. 2021;95:104411. doi: 10.1016/j.archger.2021.104411. - DOI - PMC - PubMed

[6] Damayanthi H.D.W.T., Prabani K.I.P. Nutritional determinants and COVID-19 outcomes of older patients with COVID-19: A systematic review. Arch. Gerontol. Geriatr. 2021;95:104411. doi: 10.1016/j.archger.2021.104411. - DOI - PMC - PubMed

[7] Jia H. Pulmonary Angiotensin-Converting Enzyme 2 (ACE2) and inflammatory lung disease. Shock. 2016;46:239–248. doi: 10.1097/SHK.0000000000000633. - DOI - PubMed

[8] Jia H. Pulmonary Angiotensin-Converting Enzyme 2 (ACE2) and inflammatory lung disease. Shock. 2016;46:239–248. doi: 10.1097/SHK.0000000000000633. - DOI - PubMed

[9] Shakoor H., Feehan J., Al Dhaheri A.S., Ali H.I., Platat C., Ismail L.C., Apostolopoulos V., Stojanovska L. Immune-boosting role of vitamins D, C, E, zinc, selenium and omega-3 fatty acids: Could they help against COVID-19? Maturitas. 2021;143:1–9. doi: 10.1016/j.maturitas.2020.08.003. - DOI - PMC - PubMed

[10] Shakoor H., Feehan J., Al Dhaheri A.S., Ali H.I., Platat C., Ismail L.C., Apostolopoulos V., Stojanovska L. Immune-boosting role of vitamins D, C, E, zinc, selenium and omega-3 fatty acids: Could they help against COVID-19? Maturitas. 2021;143:1–9. doi: 10.1016/j.maturitas.2020.08.003. - DOI - PMC - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Peripheral Neuropathies Derived from COVID-19: New Perspectives for Treatment

Affiliations

Peripheral Neuropathies Derived from COVID-19: New Perspectives for Treatment

Authors

Affiliations

Abstract

Conflict of interest statement

Similar articles

Cited by

References

Publication types

LinkOut - more resources

Full Text Sources