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Review
. 2022 May 6;10(5):1076.
doi: 10.3390/biomedicines10051076.

Potential and Therapeutic Roles of Diosmin in Human Diseases

Etimad Huwait  1   2 , Mohammad Mobashir  3   4
Affiliations
Review

Potential and Therapeutic Roles of Diosmin in Human Diseases

Etimad Huwait et al. Biomedicines. .

Abstract

Because of their medicinal characteristics, effectiveness, and importance, plant-derived flavonoids have been a possible subject of research for many years, particularly in the last decade. Plants contain a huge number of flavonoids, and Diosmin, a flavone glycoside, is one of them. Numerous in-vitro and in-vivo studies have validated Diosmin's extensive range of biological capabilities which present antioxidative, antihyperglycemic, anti-inflammatory, antimutagenic, and antiulcer properties. We have presented this review work because of the greater biological properties and influences of Diosmin. We have provided a brief overview of Diosmin, its pharmacology, major biological properties, such as anti-cancer, anti-diabetic, antibacterial, anticardiovascular, liver protection, and neuroprotection, therapeutic approach, potential Diosmin targets, and pathways that are known to be associated with it.

Keywords: Diosmin; anti-cancer; anti-cardiovascular; anti-diabetic; anti-inflammatory; anti-oxidant; target pathways.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
A summary of Diosmin, the associated diseases and potential properties in terms of disease protection.
Figure 2
Figure 2
Effect of Diosmin on different types of cancer cell lines and their mode of actions.
Figure 3
Figure 3
Diosmin-associated proteins and the biological pathways. We have used FunCoup database for PPI (protein–protein interactions) and integrated it with the KEGG pathways list, and the same has been mentioned in the main text also and the same has been done for Table 1 [72,73,74,75,76,77,78,79].
See this image and copyright information in PMC

References

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