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Review
. 2022 May 10;12(5):1192.
doi: 10.3390/diagnostics12051192.

The History and Future of Basic and Translational Cell-Free DNA Research at a Glance

Peter B Gahan  1 , Heidi Schwarzenbach  2 , Philippe Anker  3
Affiliations
Review

The History and Future of Basic and Translational Cell-Free DNA Research at a Glance

Peter B Gahan et al. Diagnostics (Basel). .

Abstract

We discuss the early history of the structure of DNA and its involvement in gene structure as well as its mobility in and between cells and between tissues in the form of circulating cell-free DNA (cfDNA). This is followed by a view of the present status of the studies on cfDNA and clinical applications of circulating cell-free tumor DNA (ctDNA). The future developments and roles of ctDNA are also considered.

Keywords: DNA; cancer; clinical medicine; history; methodology.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Genetic and epigenetic technologies of DNA. A descriptive summary and pictorial depiction of genetic (A) and epigenetic (B) technologies of DNA is shown. These diverse techniques were described in detail by Volik et al. [60].
See this image and copyright information in PMC

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