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. 2022 May 12;12(5):1211.
doi: 10.3390/diagnostics12051211.

PSMA-Positive Follicular Thyroid Carcinoma Incidentally Detected by [68Ga]Ga-PSMA-11 PET/CT: Correlation with Immunohistology Confirms Neovascular PSMA-Expression

Florian Rosar  1 , Caroline Burgard  1 , Christian Neubert  2 , Phillip R Stahl  3 , Fadi Khreish  1 , Samer Ezziddin  1
Affiliations

PSMA-Positive Follicular Thyroid Carcinoma Incidentally Detected by [68Ga]Ga-PSMA-11 PET/CT: Correlation with Immunohistology Confirms Neovascular PSMA-Expression

Florian Rosar et al. Diagnostics (Basel). .

Abstract

We present an interesting image of an intense PSMA-positive follicular thyroid carcinoma incidentally detected by [68Ga]Ga-PSMA-11 PET/CT in a 76-year-old man with biochemical recurrence of prostate cancer. Immunohistochemical staining demonstrated PSMA expression in the endothelial cells of tumor tissue. This interesting image should remind colleagues to consider malignant thyroid neoplasia in PSMA-positive thyroid lesions.

Keywords: PET/CT; PSMA; follicular thyroid cancer.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
[68Ga]Ga-PSMA-11 PET/CT showing intense uptake (SUVmax 32.2) in a left thyroid mass. (A) Maximum intensity projection (MIP); transversal slices of (B) PET, (C) CT, and (D) PET/CT fusion. Red arrows point to the left thyroid mass.
Figure 2
Figure 2
Histopathologic images showing minimally invasive follicular thyroid carcinoma. (A) Limited capsular penetration by the follicular neoplasia; hematoxilin–eosin (H&E) stain, magnification 50×. (B) Immunohistochemical analysis for PSMA: endothelial cells showed strong positivity in several small interfollicular vessels, magnification 200×.
See this image and copyright information in PMC

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