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. 1978 Sep 8;201(4359):937-8.
doi: 10.1126/science.356266.

Bone marrow origin of hepatic macrophages (Kupffer cells) in humans

R P Gale, R S Sparkes, D W Golde

Bone marrow origin of hepatic macrophages (Kupffer cells) in humans

R P Gale et al. Science. .

Abstract

Hepatic macrophages (Kupffer cells) from two male recipients of bone marrow transplants from females were studied for fluorescent Y body staining and sex chromatin (Barr body). After the transplant, macrophages had the sex karyotype of the donor, indicating that human hepatic macrophages originate in bone marrow.

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