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. 2022 May 23;9(5):762.
doi: 10.3390/children9050762.

Vitamin D and Forearm Fractures in Children Preliminary Findings: Risk Factors and Correlation between Low-Energy and High-Energy Fractures

Sinisa Ducic  1   2 , Filip Milanovic  1 , Mikan Lazovic  1 , Bojan Bukva  1   2 , Goran Djuricic  2   3 , Vladimir Radlovic  1   2 , Dejan Nikolic  2   4
Affiliations

Vitamin D and Forearm Fractures in Children Preliminary Findings: Risk Factors and Correlation between Low-Energy and High-Energy Fractures

Sinisa Ducic et al. Children (Basel). .

Abstract

Background: The forearm is the most common fracture site in childhood, accounting for every fourth pediatric fracture. It is well described that vitamin D is involved in the regulation of bone mineralization and skeletal homeostasis by the regulation of calcium absorption. The aim of our study was to determine the influence of 25-hydroxyvitamin D levels on forearm fracture falls in a pediatric population, depending on level of energy impact. Additionally, we also aimed to evaluate the correlation between 25-hydroxyvitamin D levels and other tested risk factors for pediatric fractures. Methods: We evaluated 50 eligible children aged 3 to 12 years with a forearm fracture. According to energy impact, patients were grouped into low-energy fractures (LEF) and high-energy fractures (HEF) groups. The general characteristics of the patients included age, gender, sport participation, and fractured bone and its localization. We analyzed 25-hydroxyvitamin D, parathyroid hormone (PTH), calcium, magnesium, phosphate, C-reactive protein (CRP) levels, and body mass index (BMI). Results: There is a significant difference in the 25-hydroxyvitamin D levels distribution between LEF and HEF (p < 0.001) and PTH levels (p = 0.002). For magnesium levels, calcium levels, phosphate levels, and CRP levels, there were no significant differences in their frequency distribution. For the group of patients with LEF, there is a significantly positive correlation between 25-hydroxyvitamin D and calcium levels (p = 0.019) and a borderline significantly positive correlation between 25-hydroxyvitamin D and magnesium levels (p = 0.050). For the group of patients with HEF, there was only a significantly positive correlation between 25-hydroxyvitamin D and PTH levels (p < 0.001). Conclusions: Children with LEF were more frequently insufficient in 25-hydroxyvitamin D levels but had normal calcium levels, compared to the ones with HEF. These findings suggest that LEF and HEF in children might to a certain degree have different pathophysiological mechanisms.

Keywords: 25-hydroxyvitamin D; bone metabolism; children; forearm; fractures.

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Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Hosseinzadeh P., Mohseni M., Minaie A., Kiebzak G.M. Vitamin D Status in Children with Forearm Fractures: Incidence and Risk Factors. J. Am. Acad. Orthop. Surg. Glob. Res. Rev. 2020;4:e20.00150-5. doi: 10.5435/JAAOSGlobal-D-20-00150. - DOI - PMC - PubMed
    1. Clark E.M. The epidemiology of fractures in otherwise healthy children. Curr. Osteoporos. Rep. 2014;12:272–278. doi: 10.1007/s11914-014-0227-y. - DOI - PubMed
    1. Rennie L., Court-Brown C.M., Mok J.Y., Beattie T.F. The epidemiology of fractures in children. Injury. 2007;38:913–922. doi: 10.1016/j.injury.2007.01.036. - DOI - PubMed
    1. Vescio A., Testa G., Sapienza M., Caldaci A., Montemagno M., Andreacchio A., Canavese F., Pavone V. Is Obesity a Risk Factor for Loss of Reduction in Children with Distal Radius Fractures Treated Conservatively? Children. 2022;9:425. doi: 10.3390/children9030425. - DOI - PMC - PubMed
    1. Saglam Y., Kizildag H., Toprak G., Alp N.B., Yalcinkaya E.Y. Prevalence of vitamin D insufficiency in children with forearm fractures. J. Child. Orthop. 2017;11:180–184. doi: 10.1302/1863-2548.11.160008. - DOI - PMC - PubMed