Analysis of Patients with Alcohol Dependence Treated in Silesian Intensive Care Units

Abstract

Analysis of patients with alcohol dependence (AD) treated in intensive care units has never been performed in Poland. Data from 25,416 adult patients identified in a Silesian Registry of Intensive Care Units were analysed. Patients with AD were identified, and their data were compared with the remaining population. Preadmission and admission variables that independently influenced ICU death in these patients were identified. Among 25,416 analysed patients, 2285 subjects (9.0%) were indicated to have AD among their comorbidities. Patients with AD were significantly younger (mean age: 53.3 ± 11.9 vs. 62.2 ± 15.5 years, p < 0.001) but had a higher mean APACHE II score at admission and were more frequently admitted to the ICU due to trauma, poisonings, acute pancreatitis, and severe metabolic abnormalities. ICU death and unfavourable outcomes were more frequent in these patients (47.8% vs. 43.0%, p < 0.001 and 54.1% vs. 47.0%, p < 0.001, respectively). Multiorgan failure as the primary cause of ICU admission was among the most prominent independent risk factors for ICU death in these patients (OR: 3.30, p < 0.001). Despite the younger age, ICU treatment of patients with AD was associated with higher mortality and a higher percentage of unfavourable outcomes.

Keywords: ICU; alcohol dependency; mortality; neurological injury.

Figure 1

Overall number of patients and the percentage of patients in various age groups.

Figure 2

Source of ICU admission in patients with and without AD.

Figure 3

Expected and observed mortalities across various ranges of APACHE II scoring results in patients with and without AD (patients with AD—(left figure), patients without AD—(right figure)).

Figure 4

Independent predictors of ICU death in patients with AD.