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. 2022 May 21;19(10):6275.
doi: 10.3390/ijerph19106275.

Association between Fathers' Use of Heated Tobacco Products and Urinary Cotinine Concentrations in Their Spouses and Children

Ayumi Onoue  1 , Yohei Inaba  2 , Kentaro Machida  3 , Takuya Samukawa  4 , Hiromasa Inoue  3 , Hajime Kurosawa  5 , Hiromitsu Ogata  6 , Naoki Kunugita  7 , Hisamitsu Omori  1
Affiliations

Association between Fathers' Use of Heated Tobacco Products and Urinary Cotinine Concentrations in Their Spouses and Children

Ayumi Onoue et al. Int J Environ Res Public Health. .

Abstract

Heated tobacco products (HTPs) have become increasingly popular among smokers, especially among young adults in Japan in recent years. Assessments of secondhand tobacco smoke (SHS) exposure due to HTPs are scarce. The present study aimed to assess the urinary levels of total nicotine metabolites (TNMs) of non-smoking spouses and their children following SHS exposure due to their fathers' use of HTPs. A total of 41 families including 129 participants were recruited between 2018 and 2021. The number of non-smoking spouses and children of the fathers who smoke combustion cigarettes, the fathers who use HTPs, and the fathers who are non-users or have never smoked was 27, 66, and 36, respectively. The urinary levels of TNMs, including cotinine (Cot) and 3'-hydroxycotinine (3-OHCot), were measured using liquid chromatography/tandem mass spectrometry (LC/MS/MS). The spouses and children of fathers who use HTPs had significantly higher levels of TNMs in their urine compared to those with fathers who were non-smokers or non-users. The current study is the first to assess SHS exposure due to HTP use, and to suggest the importance of strategies to prevent exposure to SHS from HTP use in public places and educational strategies to protect non-smokers from secondhand HTP aerosol exposure in households and other private places.

Keywords: biomarker; cotinine; heated tobacco products; secondhand smoke.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Comparison of total nicotine metabolite (TNM) urinary levels after creatine normalization among the three groups. (conc. Creatine).
See this image and copyright information in PMC

References

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