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. 2022 May 6;10(5):865.
doi: 10.3390/healthcare10050865.

Frequency of Leiden Mutation in Newborns with Birth Weight below 1500 g

Jiri Dusek  1   2 , Lenka Nedvedova  1 , Ondrej Scheinost  3 , Milan Hanzl  1 , Eva Kantorova  4 , Eva Fendrstatova  1 , Radim J Sram  5 , Hana Kotouckova  6 , Jan Voracek  7
Affiliations

Frequency of Leiden Mutation in Newborns with Birth Weight below 1500 g

Jiri Dusek et al. Healthcare (Basel). .

Abstract

It has been hypothesized that fetal prematurity or Intrauterine Growth Restriction (IUGR) could be related to the presence of factor V of Leiden mutation. This mutation is associated with a higher incidence of pregnancy difficulties that can result in preterm birth. The frequency of Leiden mutation was investigated in the group of newborns with a low birth weight below 1500 g over a six-year period from 2015 to 2020. During this period, 339 newborns were tested, of which 42 newborns with V Leiden mutation (12.4%) were detected. The average of its occurrence frequency in the Czech population was determined as 5.0% based on published studies. In our research, the occurrence of the V Leiden mutation was found significantly higher in newborns under 1500 g. At the same time, we did not demonstrate an increased frequency of births at lower gestational weeks, lower birth weight, or an association with sex in newborns with a positive diagnosis of the Leiden V factor.

Keywords: APC resistance; Leiden mutation; premature birth; thrombophilia.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Dependence of positivity on gestational age (p = 0.983).
Figure 2
Figure 2
Dependence of positivity on birth weight (p = 0.996).
Figure 3
Figure 3
Dependence on sex positivity (p = 0.574).
See this image and copyright information in PMC

References

    1. Dahlbäck B., Carlsson M., Svensson P.J. Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: Prediction of a cofactor to activated protein C. Proc. Natl. Acad. Sci. USA. 1993;90:1004–1008. doi: 10.1073/pnas.90.3.1004. - DOI - PMC - PubMed
    1. Van Cott E.M., Khor B., Zehnder J.L. Factor V Leiden. Am. J. Hematol. 2016;91:46–49. doi: 10.1002/ajh.24222. - DOI - PubMed
    1. Kujovich J., Adam M., Ardinger H., Pagon R. GeneReviews. University of Washington; Seattle, WA, USA: 2006. - PubMed
    1. Riedlova P., Kramna D., Ostrizkova S., Tomaskova H., Jirik V. Examination of in Factor V Leiden and Prothrombin II Thrombophilic Mutations in Czech Young Women Using ddPCR-Prevalence and Cost-Benefit Analysis. Healthcare. 2021;9:1656. doi: 10.3390/healthcare9121656. - DOI - PMC - PubMed
    1. Kvasnička J. Dědičné trombofílie—doporučení k provádění genetických testů v klinické praxi. Časopis Lékařů Českých. 2010;149:424–427. - PubMed

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