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. 2022 May 14;11(10):2780.
doi: 10.3390/jcm11102780.

Risk Factors Associated with Mortality among Patients with COVID-19: Analysis of a Cohort of 1213 Patients in a Tertiary Healthcare Center

Carlos Alfonso Romero-Gameros  1 , Guadalupe Vargas-Ortega  2 , Mario Enrique Rendón-Macias  3 , Carlos Fredy Cuevas-García  4 , Tania Colín-Martínez  5 , Luis Alejandro Sánchez-Hurtado  6 , Lourdes Josefina Balcázar-Hernández  2 , Iván Emilio De la Cruz-Rodríguez  2 , Enid Karina Pérez-Dionisio  2 , Perla Michelle Retana-Torres  2 , Elsy Sarahí García-Montesinos  2 , Mayra Alejandra López-Moreno  1 , Marielle Intriago-Alor  1 , Salomón Waizel-Haiat  1 , Baldomero González-Virla  2
Affiliations

Risk Factors Associated with Mortality among Patients with COVID-19: Analysis of a Cohort of 1213 Patients in a Tertiary Healthcare Center

Carlos Alfonso Romero-Gameros et al. J Clin Med. .

Abstract

The presence of cardio-metabolic and respiratory comorbidities, immunosuppression, and chronic kidney disease have been associated with an increase in mortality from COVID-19. The objective of this study is to establish the risk factors associated with 30-day mortality in a cohort of hospitalized patients with COVID-19. This paper conducts a retrospective and analytical study of patients hospitalized for COVID-19 in a tertiary care center. A Cox proportional hazard analysis was performed to estimate the association of comorbidities with 30-day mortality. A total of 1215 patients with a median age of 59 years were included. In the adjusted Cox proportional hazards regression model, hypothyroidism, D-dimer ≥ 0.8 μg/mL, LHD ≥ 430 IU/L, CRP ≥ 4.83 ng/mL, and triglycerides ≥ 214 mg/dL were associated with an increased risk of death. The presence of a history of hypothyroidism and biomarkers (D-dimer, lactic dehydrogenase, CRP, and triglycerides) were associated with an increase in mortality in the studied cohort.

Keywords: COVID-19; SARS-CoV-2; mortality; prognostic factors.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Study flow diagram.
Figure 2
Figure 2
Cox proportional hazard models for 30-day mortality in hospitalized patients with COVID-19 (n = 1215). Abbreviations: LDH, lactic dehydrogenase; T2D, type 2 diabetes; CRP, C-reactive protein; COPD, chronic pulmonary disease; and CKD, chronic kidney disease. (A) Univariate Cox proportional hazards regression model. (B) Multivariable Cox proportional hazards regression model.
Figure 3
Figure 3
Thirty-day survival of hospitalized COVID-19 patients after hospital admission, stratified by age ≥ 65 years (a) hypertension, (b) hypothyroidism, (c) ≥2 comorbidities, and (d) (n = 1215).
Figure 4
Figure 4
Thirty-day survival of hospitalized COVID-19 patients after hospital admission stratified by D-dimer ≥ 0.8 μg/mL, (a) ferritin ≥ 413.5 ng/mL, (b) C-reactive protein ≥ 4.83 mg/dL, (c) lactic dehydrogenase ≥ 430 IU/L, (d) triglycerides ≥ 214 mg/dL, and (e) (n = 1215).
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